Volume 61, Issue 1, Pages S3-S8 (January 2002)

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Volume 61, Issue 1, Pages S3-S8 (January 2002) Herpes simplex virus as a model vector system for gene therapy in renal disease Betsy C. Herold, Daniel Marcellino, Glendie Marcelin, Patricia Wilson, Christopher Burrow, Lisa M. Satlin Kidney International Volume 61, Issue 1, Pages S3-S8 (January 2002) DOI: 10.1046/j.1523-1755.2002.0610s1003.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Stimulation of cellular protein tyrosine phosphorylation after exposure to HSV-1. Vero cells were mock infected or exposed to 10 PFU/cell of HSV-1(17) for 5, 10, or 30 minutes. Cell lysates were prepared and analyzed by immunoprecipitation with PY20-agarose (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA). Immunoprecipitated proteins were detected by Western blotting with PY20, an anti-phosphotyrosine antibody (Transduction Laboratories, Lexington, KY, USA). Molecular weight standards are indicated on the left. The bars on the right identify the three cellular proteins (p80, p104, and p140) that are tyrosine phosphorylated after exposure to HSV-1. Adapted from Qie et al [32]. Kidney International 2002 61, S3-S8DOI: (10.1046/j.1523-1755.2002.0610s1003.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Effect of viral entry on intracellular Ca2+ ([Ca 2+]i) in Vero cells. Cells were loaded with the fluorescent Ca2+ indicator fura-2, and their fluorescence intensity ratios (340 nm/380 nm) were monitored before, during, and after exposure to either PBS or virus. (A) Cells were exposed to HSV(gL86) harvested from complementing cells (phenotypically wild type) and (B) to HSVgL86 harvested from Vero cells, rendering the virus able to bind but unable to penetrate the cells. Kidney International 2002 61, S3-S8DOI: (10.1046/j.1523-1755.2002.0610s1003.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Human renal tubular epithelial cells are susceptible to HSV-1 infection. Conditionally immortalized human renal collecting duct cells were infected overnight with serial dilutions of HSV-1(17)(dUTPase) from the apical (A) or basolateral (B) compartments. Monolayers were fixed and permeabilized and stained for β-galactosidase expression. Kidney International 2002 61, S3-S8DOI: (10.1046/j.1523-1755.2002.0610s1003.x) Copyright © 2002 International Society of Nephrology Terms and Conditions