Similar inflammatory response in human whole blood to live Streptococcus pneumoniae of different serotypes  P. Kragsbjerg, M. Jurstrand, H. Fredlund 

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Similar inflammatory response in human whole blood to live Streptococcus pneumoniae of different serotypes  P. Kragsbjerg, M. Jurstrand, H. Fredlund  Clinical Microbiology and Infection  Volume 10, Issue 2, Pages 174-177 (February 2004) DOI: 10.1111/j.1469-0691.2004.00726.x Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 The in-vitro production of IL-6 in human adult whole blood after incubation for 4 h at 37 °C with live Streptococcus pneumoniae. Lo = serotypes 3 and 7F; Hi = serotypes 9V and 23F. Neg = negative control, i.e., whole blood incubated without S. pneumoniae; Pos 1 ng and 0.1 ng = positive controls, i.e., whole blood incubated with lipopolysaccharide 1 ng and 0.1 ng. Clinical Microbiology and Infection 2004 10, 174-177DOI: (10.1111/j.1469-0691.2004.00726.x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 The neutrophil oxidative burst response to live Streptococcus pneumoniae using human pooled serum with known concentrations of complement and serotype-specific immunoglobulin. The results are shown as a mean percentage (+ SE) of the maximal oxidative response in four experiments. PMNL, polymorphonuclear leukocytes; SP, S. pneumoniae; Po, pooled serum; Pi, pooled serum, heat inactivated. Clinical Microbiology and Infection 2004 10, 174-177DOI: (10.1111/j.1469-0691.2004.00726.x) Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions