May the Force Be With You: Unfolding Lipid-Protein Interactions By Single-Molecule Force Spectroscopy William Dowhan, Heidi Vitrac, Mikhail Bogdanov

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May the Force Be With You: Unfolding Lipid-Protein Interactions By Single-Molecule Force Spectroscopy William Dowhan, Heidi Vitrac, Mikhail Bogdanov Structure Volume 23, Issue 4, Pages 612-614 (April 2015) DOI: 10.1016/j.str.2015.03.006 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Effect of Phosphatidylethanolamine and Phosphatidylglycerol on Structural Segments of LacY (A and B) Structural segments were mapped to the secondary structures of wild-type LacY in native (A) and inverted (B) topologies. (A) Secondary structure model of LacY (PDB ID code 1PV7) mapped with 10 structural segments S1-S10 (native topology) and (B) with 11 structural segments S1-S4, S5∗, S6∗, S6∗∗, S7∗, S8, S9, and S10 (inverted topology). TMD helices are labeled I-XII, cytoplasmic loops are labeled C1-C5, and periplasmic loops are labeled P1-P6. Figure reproduced from Serdiuk et al. (2015) with permission. Structure 2015 23, 612-614DOI: (10.1016/j.str.2015.03.006) Copyright © 2015 Elsevier Ltd Terms and Conditions