An artificial nanoemulsion carrying paclitaxel decreases the transplant heart vascular disease: A study in a rabbit graft model Domingos D. Lourenço-Filho,

Slides:

Advertisements

Similar presentations

The “occasional open heart surgeon” revisited

Advertisements

Total arterial revascularization of triple vessel coronary disease based on combined internal thoracic and radial artery grafts Robert H. Habib, PhD,

Max B. Mitchell, MD The Journal of Thoracic and Cardiovascular Surgery

Lost in translation The Journal of Thoracic and Cardiovascular Surgery

Manuel J. Antunes, MD, PhD, DSc

Stephen R. Broderick, MD, MPHS

Lucas R. Barbieri, MD, Domingos D. Lourenço-Filho, MD, PhD, Elaine R

Surgery for congenital diseases of the aorta

The impact of placing multiple grafts to each myocardial territory on long-term survival after coronary artery bypass grafting Danny Chu, MD, Faisal.

Expanding options to manage traumatic thoracic vascular injuries

Yesterday's heroic measure is now standard procedure: Extracorporeal membrane oxygenation as a bridge to lung transplant Victor van Berkel, MD, PhD

Building a bioartificial heart: A 3-song saga

Right internal thoracic artery or saphenous vein grafting

Which is more important in the potential interference on cardioprotection by remote ischemic preconditioning: β-blockers or anesthetic choice? Yang Liu,

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

Form ever follows function

Victor van Berkel, MD, PhD

William M. DeCampli, MD, PhD

Silvana Molossi, MD, PhD, Carlos M. Mery, MD, MPH

Application of a neuroscience research model to study neuroprotection in children with congenital heart disease Nobuyuki Ishibashi, MD, Richard A. Jonas,

Multilevel data analysis: What? Why? How?

Harold L. Lazar, MD The Journal of Thoracic and Cardiovascular Surgery

The lord of the rings Antonio Miceli, MD, PhD

Is tissue the issue? Brian E. Louie, MD, MHA, MPH, FRCSC, FACS

Surgical economics: MACRA, MIPS, and bundles—Lessons learned in the first 3 years of a coronary artery bypass grafting alternative payment model Daniel.

Sinus node structural changes in patients with long-standing chronic atrial fibrillation Aquilino Hurlé, MD, PhD, Vicente Climent, MD, PhD, Damian Sánchez-Quintana,

Aditya K. Kaza, MD The Journal of Thoracic and Cardiovascular Surgery

The tissue-engineered vascular graft using bone marrow without culture

Support Your Specialty

The assessment of cost effectiveness and the effectiveness of cost assessment in cardiothoracic surgery Vinay Badhwar, MD The Journal of Thoracic and.

It's not “just a shunt” but sometimes it should be…

Military surgeons just want to have fun

A first start for lung transplantation?

Stephen R. Broderick, MD, MPHS

Surgery for aortic and mitral valve disease in the United States: A trend of change in surgical practice between 1998 and 2005 Scott D. Barnett, PhD,

Joseph A. Dearani, MD, Michael J. Ackerman, MD, PhD

Chronic obstructive pulmonary disease severity influences outcomes after off-pump coronary artery bypass Benjamin Medalion, MD, Michael G. Katz, MD,

Fenton H. McCarthy, MD, MS, Nimesh D. Desai, MD, PhD

Guidelines should bother us, not comfort us

Fueling the heart: Shifting the myocardial metabolome by targeting endothelial autophagy Nicholas D. Andersen, MD The Journal of Thoracic and Cardiovascular.

Attachment disorder in thoracoabdominal surgery

Boulos Toursarkissian, MD, David Schwartz, MD, PhD, Paul R

Commentary: Do the right thing! Ethical versus legal

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

The thoracoabdominal saga and heroes

Shunt right or left? Decision 2016

Ralph S. Mosca, MD The Journal of Thoracic and Cardiovascular Surgery

The origins of open heart surgery at the University of Minnesota 1951 to 1956 Richard A. DeWall, MD The Journal of Thoracic and Cardiovascular Surgery

How much does early fundoplication for lung transplant recipients with gastroesophageal reflux disease truly help? Challenges in escaping the perils of.

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Tissue valve, nitinol stent, or storage solution

The future of cardiac surgery training: A survival guide

Apparently, size matters…in congenital heart disease and brain injury

The continuing challenge of congenital heart disease in China

Commentary: All aboard the transcatheter express—Road map for surgeons to develop expertise in catheter-based treatment of structural heart disease Grayson.

The Robin Hood principle in the treatment of congenital heart disease: Taking technologic developments intended for adults and using it in kids Paul.

The Journal of Thoracic and Cardiovascular Surgery

“The more things change…”: The challenges ahead

Appropriate Use Criteria for coronary revascularization in patients with stable ischemic heart disease: What the surgeon needs to know Harold L. Lazar,

Commentary: Just say NO

Apples remain apples NO matter what

Respect the aorta The Journal of Thoracic and Cardiovascular Surgery

Preoperative PFTs: The answer is blowing in the wind

Of mice and men… The Journal of Thoracic and Cardiovascular Surgery

Did you like Terminator 3 better than Terminator 2

How do we follow up our patients

Journal changes and initiatives

Commentary: Evaluation of primary graft dysfunction after lung transplantation—It is time to teach an old dog new tricks! W. Hampton Gray, MD, P. Michael.

Deciding how much to pay for effective care

Presentation transcript:

An artificial nanoemulsion carrying paclitaxel decreases the transplant heart vascular disease: A study in a rabbit graft model Domingos D. Lourenço-Filho, MD, PhD, Raul C. Maranhão, MD, PhD, Carlos A. Méndez-Contreras, MD, Elaine R. Tavares, BSci, Fatima R. Freitas, PhD, Noedir A. Stolf, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 141, Issue 6, Pages 1522-1528 (June 2011) DOI: 10.1016/j.jtcvs.2010.08.032 Copyright © 2011 Terms and Conditions

Figure 1 Uptake by different tissues of cholesterol-rich nanoemulsions labeled with [14C]-cholesteryl oleate ether 24 hours after intravenous injection into rabbits. ∗P = 313 versus native heart. Data are expressed as percentage uptake and normalized by gram as means ± standard errors of the mean. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 1522-1528DOI: (10.1016/j.jtcvs.2010.08.032) Copyright © 2011 Terms and Conditions

Figure 2 Immunohistochemistry of myocardial and arterial tissues from native and grafted hearts. Photomicrographs of 3,3′-Diaminobenzidine chromogen immunostaining for macrophages (A; RAM-11), (B) CD35, (C) α-actin, and (D) elastic lamina stained with Verhoeff–van Gieson stain. (Original magnifications: 100× [A, C, and D] and 200× [B].) The Journal of Thoracic and Cardiovascular Surgery 2011 141, 1522-1528DOI: (10.1016/j.jtcvs.2010.08.032) Copyright © 2011 Terms and Conditions