Supplementary Figure 1 HCT116 MOLT4

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Supplementary Figure 1 HCT116 MOLT4 Supplementary Figure 1. Quantification of histone H4 acetylation levels using high performance capillary electrophoresis. HCT116 and MOLT4 cell lines were treated for 24 hours with 1 mM of SAHA, Compound 6h or Compound 6l.

Supplementary Figure 2 HCT116 MOLT4 Supplementary Figure 2. Compounds 6h and 6l induce cell cycle arrest at G2/M. HCT116 and MOLT4 cell lines were treated for 24 hours with different concentrations (0-10 mM) of SAHA, Compound 6h or Compound 6l and the cell cycle was determined by flow citometry. The values represent the means ± SD of three separate experiments .

Supplementary Figure 3 HCT116 MOLT4 SAHA 6h 6l SAHA 6h 6l Supplementary Figure 3. Compounds 6h and 6I show antiangiogenic features. Compound 6h and Compound 6l decreased bFGF and VEGF mRNA levels. HCT116 and MOLT4 were treated with different concentrations of SAHA, Compound 6h or Compound 6l and bFGF and VEGF expression were determined by quantitative PCR.