Mahboobeh Mahdavinia, MD, PhD, Heather E

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Presentation transcript:

Effects of diet on the childhood gut microbiome and its implications for atopic dermatitis Mahboobeh Mahdavinia, MD, PhD, Heather E. Rasmussen, PhD, RDN, Maresa Botha, MD, Thi Dong Binh Tran, PhD, Jolice P. Van den Berg, MD, PhD, Erica Sodergren, PhD, Erika Davis, MS, RDN, Krista Engen, MS, RDN, Claudia Gray, MD, Nonhlanhla Lunjani, MD, Carol Hlela, MD, Nailliw Z. Preite, MSc, Wisdom Basera, MPH, Lelani Hobane, MD, Alexandra Watkins, MD, Phillip Engen, MSc, Avumile Mankahla, MD, Ben Gaunt, MD, Facey Thomas, BSc, Mary C. Tobin, MD, Alan Landay, PhD, George M. Weinstock, PhD, Ali Keshavarzian, MD, Michael E. Levin, MD Journal of Allergy and Clinical Immunology Volume 143, Issue 4, Pages 1636-1637.e5 (April 2019) DOI: 10.1016/j.jaci.2018.11.034 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, The relative abundance of P copri was significantly higher in control children without AD than in children with AD. B, The relative abundance of B Vulgatus was significantly higher in children with AD than in controls. Both P values remain significant after removing outliers for these analyses. Journal of Allergy and Clinical Immunology 2019 143, 1636-1637.e5DOI: (10.1016/j.jaci.2018.11.034) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 A, There were significant differences from multivariate dispersion (variance) at the OTU level (both ADONIS and ANOSIM, P < .001). Beta diversity analysis showed that cases with and without AD are significantly different in terms of both abundance and presence/absence of different OTUs and genera. B, Microbiome alpha-diversity indices showed that the alpha-diversity indices are not statistically different between AD and controls. ANOSIM, Analysis of group similarities. Journal of Allergy and Clinical Immunology 2019 143, 1636-1637.e5DOI: (10.1016/j.jaci.2018.11.034) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 A, The ratio of P copri was significantly higher in controls compared with controls cases. B, The analysis remained significant after excluding the 4 outliers. y-axis: The ratio is that of the number of P copri 16S genes to the number of 16S genes of all the bacteria in the sample identified using the Universal Nadkarni primers. Journal of Allergy and Clinical Immunology 2019 143, 1636-1637.e5DOI: (10.1016/j.jaci.2018.11.034) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions