Volume 68, Issue 2, Pages (August 2005)

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Volume 68, Issue 2, Pages 665-672 (August 2005) Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: Effect of diabetes Salvia Rodraguez-Mulero, Ekaitz Errasti-Murugarren, Josa Ballaran, Antonio Felipe, Alain Doucet, Fjavier Casado, Maraal Pastor- Anglada Kidney International Volume 68, Issue 2, Pages 665-672 (August 2005) DOI: 10.1111/j.1523-1755.2005.00444.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Distribution of rEAAT3 mRNAs along the rat nephron. (A) Schematic representation of a renal tubule. (B) Bars represent the mean ± SE expression of target corresponding to 2 ΔΔCT (threshold cycle), as described in theMethods section. Abbreviations are: Glom, glomerulus; PCT, proximal convoluted tubule; PST, proximal straight tubule; TDL, thin descending limb; CTAL/MTAL, cortical and medullary portion of the thick ascending limb; CCD/OMCD, cortical and outer medullary portion of the collecting duct; N.D. Not statistically different from zero. Kidney International 2005 68, 665-672DOI: (10.1111/j.1523-1755.2005.00444.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Distribution profile of concentrative nucleoside transporter (CNT) mRNAs along the rat nephron. Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis of rCNT1 (A), rCNT2 (B) and rCNT3 (C) mRNAs in the glomerulus and different segments of the rat renal tubule. Values are ±SE of measurements made on at least four animals. PCR arbitrary units were obtained as described in theMethods section. Abbreviations are: Glom, glomerulus; PCT, proximal convoluted tubule; PST, proximal straight tubule; TDL, thin descending limb; CTAL/MTAL, cortical and medullary portion of the thick ascending limb; CCD/OMCD, cortical and outer medullary portion of the collecting duct; N.D. Not statistically different from zero. Kidney International 2005 68, 665-672DOI: (10.1111/j.1523-1755.2005.00444.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Effects of 3 weeks streptozotocin-induced diabetes (STZ) and insulin treatment (STZ + INS) on urine composition. Values are ±SE of measurements made on at least four animals. **P < 0.01, values significantly different from control using analysis of variance (ANOVA) and the Dunnett post test. Kidney International 2005 68, 665-672DOI: (10.1111/j.1523-1755.2005.00444.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Effect of diabetes and insulin treatment on renal concentrative nucleoside transporter rCNT1 (A), rCTN2 (B), and CTN3 (C) mRNA distribution in the rat nephron. Values were standardized to control group for each nephron segment. Bars represent ±SE of measurements made on at least four animals. **P < 0.01, values significantly different from control using analysis of variance (ANOVA) and the Dunnett post test. Abbreviations are: Glom, glomerulus; PCT, proximal convoluted tubule; PST, proximal straight tubule; CCD, cortical collecting duct; STZ, streptozocin-induced diabetes; STZ + INS, streptozotocin and insulin-induced diabetes. Kidney International 2005 68, 665-672DOI: (10.1111/j.1523-1755.2005.00444.x) Copyright © 2005 International Society of Nephrology Terms and Conditions