Mitchell S. Cairo, Willi Woessmann, John Pagel 

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Presentation transcript:

Advances in Hematopoietic Stem Cell Transplantation in Childhood and Adolescent Lymphomas  Mitchell S. Cairo, Willi Woessmann, John Pagel  Biology of Blood and Marrow Transplantation  Volume 19, Issue 1, Pages S38-S43 (January 2013) DOI: 10.1016/j.bbmt.2012.10.003 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidences of relapse GVHD. Cumulative-relapse incidence for patients with HL after RIC acute grade II–IV or extensive chronic GVHD (20.2% [95% CI, 5.9%-69.6%]) versus those with no GVHD or with only grade I acute or limited chronic GVHD (50.7% [35.4%-72.4%]). (Reprinted from Peggs KS, Hunter A, Chopra R, et al. Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation. Lancet 2005; 365:1934-41. Copyright (2005), with permission from Elsevier.) Biology of Blood and Marrow Transplantation 2013 19, S38-S43DOI: (10.1016/j.bbmt.2012.10.003) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2A Lymphoma Cell Therapy Consortium. Geographic map of core sites and collaborating centers. Biology of Blood and Marrow Transplantation 2013 19, S38-S43DOI: (10.1016/j.bbmt.2012.10.003) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2B Treatment schema: RIC and allo-SCT followed by latent membrane protein-cytotoxic T lymphocytes (LMP-CTLs) in Patients with Epstein-Barr virus (EBV)-positive refractory/recurrent HL. Biology of Blood and Marrow Transplantation 2013 19, S38-S43DOI: (10.1016/j.bbmt.2012.10.003) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Schema of pretargeted RIT approach. Ab-SA conjugate followed by clearing agent before infusion of therapeutic radiolabeled biotin. Biology of Blood and Marrow Transplantation 2013 19, S38-S43DOI: (10.1016/j.bbmt.2012.10.003) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions