Effect of the temperature-sensitive mutation hsp90G17OD on the activity of the c-src regulatory kinase Csk and on the maturation of c-srcK295M at the semirestrictive.

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Effect of the temperature-sensitive mutation hsp90G17OD on the activity of the c-src regulatory kinase Csk and on the maturation of c-srcK295M at the semirestrictive temperature. Effect of the temperature-sensitive mutation hsp90G17OD on the activity of the c-src regulatory kinase Csk and on the maturation of c-srcK295M at the semirestrictive temperature. (A) Csk produced at 32°C: accumulation of c-srcK295M and Csk and Csk-mediated tyrosine phosphorylation of c-srcK295M in wild-type (WT) and G170D (TS) cells. (B) Csk and c-srcK295M produced at 32°C: accumulation of c-srcK295M and Csk and Csk-mediated tyrosine phosphorylation of c-srcK295M in wild-type (WT) and G170D (TS) cells. Yang Xu et al. PNAS 1999;96:1:109-114 ©1999 by National Academy of Sciences