Evaluation of tablet dosage form 1) weight variation Aram I. Ibrahim University of sulaimani College of pharmacy Dep. Of pharmaceutics

Content Introduction Causes of weight variation Procedure Limitations

Introduction Weight variations of the tablets produced is a relatively common problem of the tableting process. Each tableting process aims at producing tablets with a constant weight.

Causes of weight variation The actual cause for this problem is the lack of weighing systems for each single tablet before pressing. Each tablet press, doses a certain amount of powder into the die and this powder is then pressed. This means that a volume is dosed, not the weight. Hence, weight variations in a limited extent are quite normal due to variations in the density of the powder material and to a partially incomplete filling of the dies due to poor powder flow.

Procedure Take 20 tablets, dedust and weigh individually. Weigh all 20 tablets together and calculate average weight. Calculate % deviation for each tablet:

Limitations The tablet pass the U.S.P. test if no more that 2 tablets are out of % limit and if no tablet differs by more than 2 times of % limit.