Basophil activation test discriminates between allergy and tolerance in peanut- sensitized children Alexandra F. Santos, MD, MSc, Abdel Douiri, PhD, Natalia.

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Basophil activation test discriminates between allergy and tolerance in peanut- sensitized children Alexandra F. Santos, MD, MSc, Abdel Douiri, PhD, Natalia Bécares, BSc, Shih-Ying Wu, MSc, Alick Stephens, PhD, Suzana Radulovic, MD, Susan M.H. Chan, MD, Adam T. Fox, MD, George Du Toit, MD, Victor Turcanu, PhD, Gideon Lack, MD, FRCPCH Journal of Allergy and Clinical Immunology Volume 134, Issue 3, Pages 645-652 (September 2014) DOI: 10.1016/j.jaci.2014.04.039 Copyright © 2014 Terms and Conditions

Fig 1 BAT to peanut in PA (n = 42, A), PS (n = 31, B), and NA (n = 19, C) children. The P value refers to the comparison of the median %CD63+ basophils at selected doses between PA and PS patients: ***P < .001, **P < .01, and ns, nonsignificant. 0 represents the negative control, and anti-IgE and fMLP are the positive controls. Journal of Allergy and Clinical Immunology 2014 134, 645-652DOI: (10.1016/j.jaci.2014.04.039) Copyright © 2014 Terms and Conditions

Fig 2 ROC curves for BAT (red), SPT (blue), P-sIgE (green), and sIgE to Ara h 2 (orange) for the whole study population (n = 92) (A) and children with equivocal history, SPT, and sIgE to peanut and its components (n = 39) (B). For BAT, the average between %CD63+ basophils at 10 and 100 ng/mL of peanut extract was considered. For area under the ROC curves for different tests in the 2 study populations, see Table E5. Journal of Allergy and Clinical Immunology 2014 134, 645-652DOI: (10.1016/j.jaci.2014.04.039) Copyright © 2014 Terms and Conditions