Activity-Based Profiling for Drug Discovery

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Activity-Based Profiling for Drug Discovery Remigiusz Serwa, Edward W. Tate Chemistry & Biology Volume 18, Issue 4, Pages 407-409 (April 2011) DOI: 10.1016/j.chembiol.2011.04.002 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Discovery of JW480: Activity-Based Protein Profiling in Action ABPP-assisted discovery of selective inhibitor JW480 against serine protease KIAA1363, the activity of which is upregulated in aggressive cancer cells. Orally administered JW480 also significantly impaired the growth of tumor in a mouse xenograph model. Chemistry & Biology 2011 18, 407-409DOI: (10.1016/j.chembiol.2011.04.002) Copyright © 2011 Elsevier Ltd Terms and Conditions