Expression of Nuclear Factor-κB and Its Clinical Significance in Nonsmall-Cell Lung Cancer Zhenfa Zhang, MD, Jianqun Ma, MD, Ni Li, PhD, Nan Sun, MD,

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Expression of Nuclear Factor-κB and Its Clinical Significance in Nonsmall-Cell Lung Cancer Zhenfa Zhang, MD, Jianqun Ma, MD, Ni Li, PhD, Nan Sun, MD, Changli Wang, BM The Annals of Thoracic Surgery Volume 82, Issue 1, Pages 243-248 (July 2006) DOI: 10.1016/j.athoracsur.2006.01.049 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Expression of nuclear factor (NF)-κB in nonsmall-cell lung cancer by Western blotting. Lung cancer tissue samples were analyzed by probing with an anti–NF-κB polyclonal antibody. The blots were subsequently probed with anti-actin antibody as a loading control. The expression level of NF-κB in each band was semiquantified by calculating the ratio of NF-κB to β-actin. The Annals of Thoracic Surgery 2006 82, 243-248DOI: (10.1016/j.athoracsur.2006.01.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Scatter graph for correlation between nuclear factor (NF)-κB and caspase-3, p53, and COX-2. (A) Expression of NF-κB and caspase-3. The linear regression equation was y = 0.930 - 0.847x (p = 0.000), and the correlation coefficient was -0.789 (p = 0.000). (B) Expression of NF-κB and p53. The linear regression equation was y = 0.218 + 0.768x (p = 0.000), and the correlation coefficient was 0.825 (p = 0.000). (C) Expression of NF-κB and COX-2. The linear regression equation was y = 0.371 + 0.766x (p = 0.000), and the correlation coefficient was 0.705 (p = 0.000). The Annals of Thoracic Surgery 2006 82, 243-248DOI: (10.1016/j.athoracsur.2006.01.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 This chart illustrates the correlation between expression of nuclear factor (NF)-κB and overall survival among patients with nonsmall-cell lung cancer. Survival distributions were calculated with the Kaplan-Meier method and were compared in a log-rank analysis (+: censored; p = 0.0018). Nuclear factor-κB is expressed as ratio to actin expression. Nuclear factor-κB(-): median survival time, 52 months; 95% confidence interval: 48 to 55. Nuclear factor-κB(+): median survival time, 20 months; 95% confidence interval: 17 to 23. The Annals of Thoracic Surgery 2006 82, 243-248DOI: (10.1016/j.athoracsur.2006.01.049) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions