Volume 149, Issue 2, Pages 367-378.e5 (August 2015) Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis  Eduardo Vilar-Gomez, Yadina Martinez-Perez, Luis Calzadilla-Bertot, Ana Torres-Gonzalez, Bienvenido Gra-Oramas, Licet Gonzalez- Fabian, Scott L. Friedman, Moises Diago, Manuel Romero-Gomez  Gastroenterology  Volume 149, Issue 2, Pages 367-378.e5 (August 2015) DOI: 10.1053/j.gastro.2015.04.005 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 Flow of participants through the study. ∗Overall outcomes were imputed using a model of multiple imputations. Gastroenterology 2015 149, 367-378.e5DOI: (10.1053/j.gastro.2015.04.005) Copyright © 2015 AGA Institute Terms and Conditions

Figure 2 Correlation between weight-loss percentage and improvement of different histologic parameters related to NASH. (A) Resolution of steatohepatitis, (B) NAS improvement, (C) steatosis improvement, (D) lobular inflammation improvement, (E) ballooning improvement, (F) Fibrosis status. Spearman's correlation (ρ) coefficients were computed to determine correlation between weight losses (%) and histologic features improvements. Dashed lines represent mean weight loss (%) values. Patients with small difference in the amounts of weight loss (eg, 3.2, 3.4, and 3.6) can be included in the same circle. Mean weight loss for histologic outcomes: Resolution of steatohepatitis (yes, 8.34; 95% confidence interval [CI]: 7.34−9.33]; no, 2.48; 95% CI: 2.08−2.88), NAS improvement (yes, 6.17; 95% CI: 5.41−6.93; no, 1.91; 95% CI: 1.50−2.32), steatosis improvement (yes, 6.16; 95% CI: 5.43−6.88; no, 1.81; 95% CI: 1.39−2.24), lobular inflammation improvement (yes, 5.89; 95% CI: 5.14−6.64; no, 1.94; 95% CI: 1.53−2.34), ballooning improvement (yes, 6.10; 95% CI: 5.24−6.95; no, 2.51; 95% CI: 2.05−2.98), fibrosis status (regressed, 5.39; 95% CI: 4.01−6.76; stabilized, 3.91; 95% CI: 3.34−4.49; worsened, 2.38; 95% CI: 1.48−3.27). Gastroenterology 2015 149, 367-378.e5DOI: (10.1053/j.gastro.2015.04.005) Copyright © 2015 AGA Institute Terms and Conditions

Figure 3 Weight-loss categories and changes in the fibrosis status at the end of intervention. Analysis stratifying by presence of baseline fibrosis. (A) Presence of baseline fibrosis, (B) absence of baseline fibrosis. ∗P values for the Mantel-Haenszel χ2 test for trend stratified by age older than 55 years, sex, BMI ≥35, type 2 diabetes, medication of diabetes/hyperlipidemia, and baseline fibrosis score. Gastroenterology 2015 149, 367-378.e5DOI: (10.1053/j.gastro.2015.04.005) Copyright © 2015 AGA Institute Terms and Conditions