Hisham S. Bassiouny, MD, Yashuhiro Sakaguchi, MD, Susanne A

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Presentation transcript:

Juxtalumenal location of plaque necrosis and neoformation in symptomatic carotid stenosis Hisham S. Bassiouny, MD, Yashuhiro Sakaguchi, MD, Susanne A. Mikucki, MD, PhD, James F. McKinsey, MD, Giancarlo Piano, MD, Bruce L. Gewertz, MD, Seymour Glagov, MD Journal of Vascular Surgery Volume 26, Issue 4, Pages 585-594 (October 1997) DOI: 10.1016/S0741-5214(97)70056-9 Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Diagram of section levels in carotid bifurcation specimens. Journal of Vascular Surgery 1997 26, 585-594DOI: (10.1016/S0741-5214(97)70056-9) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Illustration represents computer-assisted morphometric analysis of plaque cross-sections. As shown, individual plaque components were contour-traced and distance between each component and fibrous cap and lumen were measured. Distance between necrotic core and fibrous cap or lumen is represented by a and b. Distance between calcification and fibrous cap or lumen is represented by c and d. Journal of Vascular Surgery 1997 26, 585-594DOI: (10.1016/S0741-5214(97)70056-9) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Photomicrograph of a histologic section (original magnification, ×25) in a symptomatic plaque representing fibrous cap thinning and erosion with exposure of the necrotic core to the lumen. Journal of Vascular Surgery 1997 26, 585-594DOI: (10.1016/S0741-5214(97)70056-9) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Photomicrograph (original magnification ×15) illustrates well-developed fibrous cap isolating plaque necrotic core from lumen in asymptomatic plaque. Journal of Vascular Surgery 1997 26, 585-594DOI: (10.1016/S0741-5214(97)70056-9) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Scattergram represents values of the distance between the necrotic core and the fibrous cap (A) and the lumen (B). Journal of Vascular Surgery 1997 26, 585-594DOI: (10.1016/S0741-5214(97)70056-9) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Scattergram represents values of the distance between the necrotic core and the fibrous cap (A) and the lumen (B). Journal of Vascular Surgery 1997 26, 585-594DOI: (10.1016/S0741-5214(97)70056-9) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Immunohistochemical staining of macrophages infiltrating the fibrous cap using mouse antihuman macrophage antibody (original magnification, ×50). Journal of Vascular Surgery 1997 26, 585-594DOI: (10.1016/S0741-5214(97)70056-9) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions