Dexmedetomidine pharmacodynamics in healthy volunteers: 2

Slides:

Advertisements

Similar presentations

S. Arenas-Lopez, H. Mulla, S. Manna, A. Durward, I. A. Murdoch, S. M

Advertisements

Comparison of continuous non-invasive finger arterial pressure monitoring with conventional intermittent automated arm arterial pressure measurement in.

Relationship between Bispectral Index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints M. Iannuzzi,

Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia M Hara, K Masui, D.J. Eleveld,

Bispectral index values and propofol concentrations at loss and return of consciousness in patients with frontal brain tumours and control patients M.M.

Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems N Sigmond,

Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane R.I. Westphalen,

C.-A. Ewaldsson, R.G. Hahn British Journal of Anaesthesia

Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized,

Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation† G.A. Hans, S.M. Lauwick, A.

M. M. Sahinovic, D. J. Eleveld, T Miyabe-Nishiwaki, M. M. R. F

AnestAssist British Journal of Anaesthesia

Dexmedetomidine vs propofol-remifentanil conscious sedation for awake craniotomy: a prospective randomized controlled trial† ‡ N Goettel, S Bharadwaj,

Influence of steep Trendelenburg position and CO2 pneumoperitoneum on cardiovascular, cerebrovascular, and respiratory homeostasis during robotic prostatectomy

Stimulation induced variability of pulse plethysmography does not discriminate responsiveness to intubation M Luginbu¨hl, M Ru¨fenacht, I Korhonen, M.

Pharmacokinetic and pharmacodynamic interactions in anaesthesia

M. M. R. F. Struys, M. Sahinovic, B. J. Lichtenbelt, H. E. M

Pharmacokinetic/pharmacodynamic model for unfractionated heparin dosing during cardiopulmonary bypass X. Delavenne, E. Ollier, S. Chollet, F. Sandri,

M. Klein, L. Minkovich, M. Machina, M. Selzner, V. N. Spetzler, J. M

Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery S.Y. Kim, J.M. Kim, J.H. Lee,

Wide inter-individual variability of bispectral index and spectral entropy at loss of consciousness during increasing concentrations of dexmedetomidine,

Enhancing a sedation score to include truly noxious stimulation: the Extended Observer's Assessment of Alertness and Sedation (EOAA/S) T.K. Kim, P.J.

A.R. Absalom, V. Mani, T. De Smet, M.M.R. F. Struys

Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: performance of three.

J.-Y. Hwang, H.-S. Na, Y.-T. Jeon, Y.-J. Ro, C.-S. Kim, S.-H. Do

Pharmacokinetics of intravenous emulsified isoflurane in beagle dogs

Pharmacokinetics of intranasal fentanyl in parturient

S. Kreuer, J. Bruhn, R. Larsen, M. Hoepstein, W. Wilhelm

L. I. Cortínez, B. J. Anderson, A Penna, L Olivares, H. R. Muñoz, N. H

T. Ledowski, J. Burke, J. Hruby British Journal of Anaesthesia

N. H. Sperna Weiland, J. Hermanides, M W Hollmann, B

Attenuation of high-frequency (30–200 Hz) thalamocortical EEG rhythms as correlate of anaesthetic action: evidence from dexmedetomidine G. Plourde, F.

T. Iirola, H. Ihmsen, R. Laitio, E. Kentala, R. Aantaa, J. -P

Accuracy of non-invasive measurement of haemoglobin concentration by pulse co- oximetry during steady-state and dynamic conditions in liver surgery J.J.

Spectral entropy measurement of patient responsiveness during propofol and remifentanil. A comparison with the bispectral index† Vanluchene A.L.G. ,

Evaluation of the effect of intravenous lidocaine on propofol requirements during total intravenous anaesthesia as measured by bispectral index† F.R.

R. E. Kallionpää, A. Scheinin, R. A. Kallionpää, N. Sandman, M

Detection of awareness in surgical patients with EEG-based indices—bispectral index and patient state index†‡ G. Schneider, A.W. Gelb, B. Schmeller,

Development of acute tolerance to the EEG effect of propofol in rats†

Influence of nociceptive stimulation on analgesia nociception index (ANI) during propofol–remifentanil anaesthesia M. Gruenewald, C. Ilies, J. Herz,

J.E. Hall, T.D. Uhrich, T.J. Ebert British Journal of Anaesthesia

Dexmedetomidine pharmacokinetic–pharmacodynamic modelling in healthy volunteers: 1. Influence of arousal on bispectral index and sedation P.J. Colin,

High inspired oxygen concentration increases the speed of onset of remifentanil- induced respiratory depression A Dahan, M Douma, E Olofsen, M Niesters

Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia C. Jeleazcov, M. Lavielle, J. Schüttler,

Does bispectral analysis add anything but complexity

Population pharmacokinetics of ε-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery P.A. Stricker, M.R. Gastonguay, D. Singh,

Patient state index vs bispectral index as measures of the electroencephalographic effects of propofol M Soehle, M Kuech, M Grube, S Wirz, S Kreuer,

Bispectral index is related to the spread of spinal sensory block in patients with combined spinal and general anaesthesia R Iida, K Iwasaki, J Kato,

Optimization of desflurane administration in morbidly obese patients: a comparison with sevoflurane using an ‘inhalation bolus’ technique L.E.C. De Baerdemaeker,

Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers A. Snapir, P. Talke, J. Posti, M.

Non-invasive continuous arterial pressure measurement based on radial artery tonometry in the intensive care unit: a method comparison study using the.

Predictive performance of the modified Marsh and Schnider models for propofol in underweight patients undergoing general anaesthesia using target-controlled.

J.G. Hardman, J.S. Wills British Journal of Anaesthesia

Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers A.R. Absalom,

Do old pharmacokinetic parameter estimates predict new data?

Effects of short-term simultaneous infusion of dobutamine and terlipressin in patients with septic shock: the DOBUPRESS study† A. Morelli, C. Ertmer,

Effect of phenylephrine on the haemodynamic state and cerebral oxygen saturation during anaesthesia in the upright position P.F. Soeding, S Hoy, G Hoy,

The effect of ephedrine on intubating conditions and haemodynamics during rapid tracheal intubation using propofol and rocuronium M.D. Gopalakrishna,

Model-based administration of inhalation anaesthesia. 4

Comparative total and unbound pharmacokinetics of cefazolin administered by bolus versus continuous infusion in patients undergoing major surgery: a randomized.

Effects of remifentanil on cardiovascular and bispectral index responses to endotracheal intubation in severe pre-eclamptic patients undergoing Caesarean.

NAP5: the tip of the iceberg, or all we need to know?

Reduction of vasopressor requirement by hydrocortisone administration in a patient with cerebral vasospasm J.A. Alhashemi British Journal of Anaesthesia

Haemodynamic effects of oxytocin given as i. v

Nitrous oxide does not produce a clinically important sparing effect during closed-loop delivered propofol–remifentanil anaesthesia guided by the bispectral.

Takamatsu I. , Ozaki M. , Kazama T. British Journal of Anaesthesia

Unconscious learning during surgery with propofol anaesthesia†

Relationship between Bispectral Index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints M. Iannuzzi,

Closed-loop control of propofol anaesthesia using bispectral index™: performance assessment in patients receiving computer-controlled propofol and manually.

Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing.

Presentation transcript:

Dexmedetomidine pharmacodynamics in healthy volunteers: 2 Dexmedetomidine pharmacodynamics in healthy volunteers: 2. Haemodynamic profile P.J. Colin, L.N. Hannivoort, D.J. Eleveld, K.M.E.M. Reyntjens, A.R. Absalom, H.E.M. Vereecke, M.M.R.F. Struys British Journal of Anaesthesia Volume 119, Issue 2, Pages 211-220 (August 2017) DOI: 10.1093/bja/aex086 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Mean arterial pressure (continuous pink lines; grey y-axis labels) and heart rate (solid blue lines; black y-axis labels) for four representative subjects. The nominal times (as indicated by the study protocol) at which TCI settings were changed are indicated by vertical dashed lines. A bolus infusion was followed by a 10 min recovery period, after which (the first dashed line indicates the end of this phase) TCI targets were increased in a stepwise fashion. HR, heart rate; MAP, mean arterial pressure; TCI, target-controlled infusion. British Journal of Anaesthesia 2017 119, 211-220DOI: (10.1093/bja/aex086) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 Change in mean arterial pressure (continuous blue line) and heart rate (dashed black line) for a typical 20-yr-old individual, as a function of the respective effect-site concentrations. Ce, effect-site concentration; HR, heart rate; MAP, mean arterial pressure. British Journal of Anaesthesia 2017 119, 211-220DOI: (10.1093/bja/aex086) Copyright © 2017 The Author(s) Terms and Conditions

Fig 3 Influence of dexmedetomidine dose (top panels) and infusion duration (lower panels) on mean arterial pressure (left panels) and heart rate (right panels) for short (30 min at most) infusions. BaseHR, baseline heart rate; BaseMAP, baseline mean arterial pressure. British Journal of Anaesthesia 2017 119, 211-220DOI: (10.1093/bja/aex086) Copyright © 2017 The Author(s) Terms and Conditions

Fig 4 Post hoc predicted change in BIS (top panels) and probability for loss of MOAA/S 3 (bottom panels) as a function of the simultaneous change in heart rate (left panels) and mean arterial pressure (right panels). The individually predicted trajectories for all subjects are shown with green continuous lines. The population average trajectory is shown with a thick continuous blue line. Clinically interesting targets for BIS and probability for loss of MOAA/S 3 are shown with grey shaded areas. BIS, bispectral index; HR, heart rate; MAP, mean arterial pressure; MOAA/S, Modified Observer's Assessment of Alertness/Sedation; Pr, predicted. British Journal of Anaesthesia 2017 119, 211-220DOI: (10.1093/bja/aex086) Copyright © 2017 The Author(s) Terms and Conditions