A. Salonen, J. Salojärvi, L. Lahti, W.M. de Vos

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Presentation transcript:

The adult intestinal core microbiota is determined by analysis depth and health status A. Salonen, J. Salojärvi, L. Lahti, W.M. de Vos Clinical Microbiology and Infection Volume 18, Pages 16-20 (July 2012) DOI: 10.1111/j.1469-0691.2012.03855.x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Overview of the total phylotype richness in 115 healthy subjects. Rarefaction curve showing the number of phylotypes (y-axis) that are detected after analysing the number of subjects shown on the x-axis. Dashed lines indicate the 95% confidence intervals of the mean. Clinical Microbiology and Infection 2012 18, 16-20DOI: (10.1111/j.1469-0691.2012.03855.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Definition of the common core microbiota. (a) Perspective plot visualizing the number of core phylotypes as a function of the prevalence and abundance (indicated as logarithmic values of the signal intensity). (b) The common core size in 115 healthy subjects. The y-axis represents the number of shared phylotypes at different abundance (logarithmic values of the signal intensity, x-axis). Clinical Microbiology and Infection 2012 18, 16-20DOI: (10.1111/j.1469-0691.2012.03855.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Averaged, abundance-independent core size in 115 healthy subjects. In order to refrain from using predefined abundance thresholds in the definition of the core, an average core was calculated by bootstrapping the signal intensities and supposing 100% prevalence. Dashed lines indicate the 95% confidence intervals of the mean. Clinical Microbiology and Infection 2012 18, 16-20DOI: (10.1111/j.1469-0691.2012.03855.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Impact of health status in the common core microbiota. (a) The core size of the intestinal microbiota of 12 healthy subjects (black), 12 patients suffering from UC (red) and their pooled combination (blue) was calculated by bootstrapping. Dashed lines indicate the 95% confidence intervals for the healthy core. (b) Venn diagram showing the compositional overlap between the UC and healthy core. The phylotypes constituting the cores were compared as explained in detail in the text. Clinical Microbiology and Infection 2012 18, 16-20DOI: (10.1111/j.1469-0691.2012.03855.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions