Figure 2 Pathophysiological mechanisms in LGMD

Slides:

Advertisements

Similar presentations

Table 3 Limb-girdle muscular dystrophy standardized data collection form and HPO mapping Thompson, R. & Straub, V. et al. (2016) Limb-girdle muscular dystrophies.

Advertisements

Nat. Rev. Neurol. doi:10/1038/nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Proteins involved in muscular dystrophies

Figure 3 Life expectancy at birth in all countries included

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 The US Centers for Disease Control and

Figure 4 Time course of the development of physiological changes

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Carotid artery inflammation detected using 18F-FDG-PET

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 Overview of risk factors for Parkinson disease dementia

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 General framework of brain–computer interface (BCI) systems

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 Functional mechanisms of ASOs

Figure 3 Proportion of patients for whom NEDA

Figure 5 Number of AHSCT procedures for

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 The network of chronic diseases and their mutual influences

Figure 2 Three distinct mechanisms of activation of

Figure 7 Defects in apoptosis

Figure 3 Nucleic acid sensors in SLE

Figure 2 Co-stimulatory receptors as immunomodulatory targets

Figure 1 Diagnostic tiers of Parkinson disease as single disease

Figure 3 Translational research projects in LGMD

Figure 3 Hypothetical mechanisms of smoking-associated

Figure 2 Algorithm for immunosuppressive treatment

Figure 2 Precision medicine based on a network approach

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Principles of therapeutic ultrasound

Figure 2 Endocrine dysfunction in mitochondrial disease and their associated gene defects Figure 2 | Endocrine dysfunction in mitochondrial disease and.

Figure 1 Critical signalling pathways involved in PDAC pathogenesis

Figure 1 Clinical correlates of neurodegeneration in MS

Figure 3 Genetic pleiotropy in ALS

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Evolution of multiple sclerosis

Figure 4 Generation of tau seeds and spread of tau pathology

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Figure 4 Diverse molecular mechanisms of long non-coding RNAs

Nat. Rev. Neurol. doi: /nrneurol

Figure 3 Stroke-related deaths and DALYs by country development status

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 Carotid artery inflammation detected using 68Ga-DOTATATE-PET

Figure 6 Combining population-wide and high-risk strategies

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 Logistical requirements for autologous

Figure 3 Potential interplay between physiological

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 1 Clinical aspects of LGMD subtypes

Figure 1 Tau PET images in patients with Alzheimer disease

Figure 2 Cellular pathways implicated in CIPN

Figure 1 Genetic profile of 90 patients with dysferlin deficiency

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 Timing of the effects of deep brain stimulation

Figure 1 A large number of genes are potentially associated with CIPN

Nat. Rev. Neurol. doi: /nrneurol

Figure 3 Blood–brain barrier breakdown promotes neurodegeneration

Nat. Rev. Cardiol. doi: /nrcardio

Figure 2 Network connections of the hypothalamus

Milk-associated proteomes.

Presentation transcript:

Figure 2 Pathophysiological mechanisms in LGMD Figure 2 | Pathophysiological mechanisms in LGMD. The various forms of LGMD do not share a common pathophysiological mechanism. Depending on the specific protein function that is defective, different pathways and subcellular structures can be involved, including the dystrophin–glycoprotein complex, the sarcomere, glycosylation of dystroglycan, vesicle and molecular trafficking, signal transduction pathways, and nuclear functions. Some of the proteins that are relevant to LGMD can be involved in several pathways and, in this figure, structures and diseases have been assigned to pathophysiological categories on the basis of generic concepts. LGMD, limb-girdle muscular dystrophy. Thompson, R. & Straub, V. et al. (2016) Limb-girdle muscular dystrophies — international collaborations for translational research Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.35