Patients With Severe Aortic Valve Stenosis and Impaired Platelet Function Benefit From Preoperative Desmopressin Infusion Barbara Steinlechner, MD, Petra.

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Presentation transcript:

Patients With Severe Aortic Valve Stenosis and Impaired Platelet Function Benefit From Preoperative Desmopressin Infusion Barbara Steinlechner, MD, Petra Zeidler, MD, Eva Base, MD, Beatrice Birkenberg, MD, Hendrik Jan Ankersmit, MD, Michael Spannagl, MD, Peter Quehenberger, MD, Michael Hiesmayr, MD, Bernd Jilma, MD The Annals of Thoracic Surgery Volume 91, Issue 5, Pages 1420-1426 (May 2011) DOI: 10.1016/j.athoracsur.2011.01.052 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 The desmopressin enhances von Willebrand factor indices as compared with placebo in patients with severe aortic stenosis undergoing valve replacement. Data are presented as means and 95% confidence intervals. (Ag = antigen; CBA = collagen binding activity; GpIb = glycoprotein Ib binding activity; RCo = ristocetin cofactor activity; VWF = von Willebrand factor; ***p < 0.001 between groups; ■ = desmopressin; ○ = placebo.) The Annals of Thoracic Surgery 2011 91, 1420-1426DOI: (10.1016/j.athoracsur.2011.01.052) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Typical multimer pattern of von Willebrand Factor in patients with severe aortic stenosis in the current trial. The Annals of Thoracic Surgery 2011 91, 1420-1426DOI: (10.1016/j.athoracsur.2011.01.052) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 The desmopressin rapidly normalizes primary hemostasis as measured by the platelet function analyzer in patients with severe aortic stenosis undergoing valve replacement. Data are presented as means and 95% confidence intervals. (***p < 0.001 between groups; ■ = desmopressin; ○ = placebo.) The Annals of Thoracic Surgery 2011 91, 1420-1426DOI: (10.1016/j.athoracsur.2011.01.052) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions