Volume 15, Issue 2, Pages (February 2018)

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Volume 15, Issue 2, Pages 159-163 (February 2018) Class IC antiarrhythmic drugs for suspected premature ventricular contraction–induced cardiomyopathy Matthew C. Hyman, MD, PhD, Danielle Mustin, BS, Gregory Supple, MD, Robert D. Schaller, DO, Pasquale Santangeli, MD, PhD, Jeffrey Arkles, MD, David Lin, MD, FHRS, Daniele Muser, MD, Sanjay Dixit, MD, FHRS, Saman Nazarian, MD, PhD, Andrew E. Epstein, MD, FHRS, David J. Callans, MD, FHRS, Francis E. Marchlinski, MD, FHRS, David S. Frankel, MD, FHRS Heart Rhythm Volume 15, Issue 2, Pages 159-163 (February 2018) DOI: 10.1016/j.hrthm.2017.12.018 Copyright © 2017 Heart Rhythm Society Terms and Conditions

Figure 1 Screening method used to identify patients with suspected premature ventricular contraction-induced cardiomyopathy (PVC-CM) who were prescribed Class IC antiarrhythmic drugs (IC-AADs). ICD = International Classification of Disease. Heart Rhythm 2018 15, 159-163DOI: (10.1016/j.hrthm.2017.12.018) Copyright © 2017 Heart Rhythm Society Terms and Conditions

Figure 2 Premature ventricular contraction (PVC) burden and left ventricular ejection fraction (LVEF) before and after Class IC antiarrhythmic drug (IC-AAD) treatment. A: PVC burden before and after treatment with IC-AAD among the entire study cohort. B: LVEF before and after treatment with IC-AAD among the entire study cohort. C: PVC burden before and after treatment with IC-AAD among the 7 patients with myocardial delayed enhancement on cardiac magnetic resonance imaging (MRI). D: LVEF before and after treatment with IC-AAD among the 7 patients with myocardial delayed enhancement on cardiac MRI. Heart Rhythm 2018 15, 159-163DOI: (10.1016/j.hrthm.2017.12.018) Copyright © 2017 Heart Rhythm Society Terms and Conditions

Figure 3 Time course of improvement in left ventricular ejection fraction (LVEF) after Class IC antiarrhythmic drug initiation. Mean LVEF for the entire study cohort is displayed at each time point. Heart Rhythm 2018 15, 159-163DOI: (10.1016/j.hrthm.2017.12.018) Copyright © 2017 Heart Rhythm Society Terms and Conditions