Volume 67, Issue 6, Pages (December 2017)

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Volume 67, Issue 6, Pages 1358-1359 (December 2017) Addendum to “MicroRNA profiles in graft preservation solution are predictive of ischemic-type biliary lesions after liver transplantation” [J Hepatol 2013;59:1231–1238] Cornelia J. Verhoeven, Jasmijn W. Selten, Henk P. Roest, Waqar R.R. Farid, Petra E. de Ruiter, Bettina E. Hansen, Jeroen de Jonge, Jaap Kwekkeboom, Herold J. Metselaar, Hugo W. Tilanus, Geert Kazemier, Jan N.M. IJzermans, Luc J.W. van der Laan Journal of Hepatology Volume 67, Issue 6, Pages 1358-1359 (December 2017) DOI: 10.1016/j.jhep.2017.09.001 Copyright © 2017 Terms and Conditions

Fig. 1 Heparinase I treatment improves miRNA detection in perfusates of liver grafts and the predictive value for ischemic-type biliary lesions (ITBL) after transplantation. (A) Relative miRNA levels in 57 perfusates before (−) and after (+) heparinase I treatment for HDmiR-148a and CDmiR-296 and miR-148a/miR-296 ratio. The detections and ratios increased significantly after heparinase I treatment. Unreliable detection area is indicated in grey. (B) Heparinase I treatment improved the prognostic value of HDmiRs/CDmiRs ratios for ITBL. All boxplots indicate mean±95% confidence interval. (C) Grafts with high perfusate HDmiR-148a/CDmiR-296 ratio (top 50%) have a significantly higher incidence of ITBL after transplantation (Log-rank test), both in the entire cohort and the subset of DBD grafts. (D) In univariate and multivariate analysis, the predictive value of HDmiR/CDmiR ratios as independent risk factor for ITBL were further improved after heparinase I treatment. Shown are the old (as previous published) and new (after heparinase I treatment) HRs, the new p value and 95% CI. *In the multivariate model for ITBL, separate HDmiR/CDmiR ratios were adjusted for graft type (DBD vs. DCD) and the type of solution used for graft preservation (UW vs. HTK), identical to previous analysis. CDmiRs, cholangiocyte-derived miRNAs; CI, confidence interval; DBD, donated after brain death; DCD, donation after cardiac death; HDmiRs, hepatocyte-derived miRNAs; HR, hazard ratio; ITBL, ischemic-type biliary lesions, miRNAs, microRNAs; N.S., not significant. Journal of Hepatology 2017 67, 1358-1359DOI: (10.1016/j.jhep.2017.09.001) Copyright © 2017 Terms and Conditions