Articular cartilage MR imaging and thickness mapping of a loaded knee joint before and after meniscectomy Y. Song, M.S., J.M. Greve, M.S., D.R. Carter,

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Articular cartilage MR imaging and thickness mapping of a loaded knee joint before and after meniscectomy Y. Song, M.S., J.M. Greve, M.S., D.R. Carter, Ph.D., S. Koo, M.S., N.J. Giori, M.D., Ph.D Osteoarthritis and Cartilage Volume 14, Issue 8, Pages 728-737 (August 2006) DOI: 10.1016/j.joca.2006.01.011 Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 (a) A front view and (b) perspective drawing of the pneumatic loading apparatus are shown. Osteoarthritis and Cartilage 2006 14, 728-737DOI: (10.1016/j.joca.2006.01.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 A schematic diagram of the air flow control device is shown. Osteoarthritis and Cartilage 2006 14, 728-737DOI: (10.1016/j.joca.2006.01.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 The specimen preparation steps are shown. (a) The sheep knee is frozen at 45 degrees of flexion. (b) The entire tibio-femoral joint is cored using a 4.5cm hole saw. (c) The cylindrical specimen includes the entire tibio-femoral joint, both menisci, and all collateral and cruciate ligaments. Osteoarthritis and Cartilage 2006 14, 728-737DOI: (10.1016/j.joca.2006.01.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 Diagrams illustrating the (a) thickness measurement, and (b) deformation calculation are shown. Osteoarthritis and Cartilage 2006 14, 728-737DOI: (10.1016/j.joca.2006.01.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Sample sagittal MRI slices through the center of the medial condyle of an unloaded knee and a statically loaded intact knee. Osteoarthritis and Cartilage 2006 14, 728-737DOI: (10.1016/j.joca.2006.01.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 6 Tibial contact area is shown in blue (left) and articular cartilage thickness maps are shown (right) for three different loading conditions; (a) unloaded intact, (b) statically loaded intact, and (c) statically loaded after medial meniscectomy. Osteoarthritis and Cartilage 2006 14, 728-737DOI: (10.1016/j.joca.2006.01.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 7 Nominal strain maps of tibial articular cartilage under static compressive load are shown: (a) intact and (b) following medial meniscectomy. Osteoarthritis and Cartilage 2006 14, 728-737DOI: (10.1016/j.joca.2006.01.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 8 Changes of low (L), moderate (M) and high (H) deformation areas due to medial meniscectomy on (a) medial and (b) lateral tibial articular cartilage are shown. Osteoarthritis and Cartilage 2006 14, 728-737DOI: (10.1016/j.joca.2006.01.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions