The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful.

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The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis C.Y.J. Wenham, S. Balamoody, A.J. Grainger, E.M.A. Hensor, S. Draycott, R. Hodgson, P.G. Conaghan Osteoarthritis and Cartilage Volume 22, Issue 10, Pages 1614-1618 (October 2014) DOI: 10.1016/j.joca.2014.05.024 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 a) Time-signal enhancement curves demonstrating synovial enhancement (y axis) after intravenous gadolinium contrast (x axis represents time in seconds post gadoliunium contrast), before (dark grey line) and after (light grey line) IACS. The EER was calculated at 60 s (x axis). b): Time-signal enhancement curves demonstrating synovial enhancement (y axis) after intravenous gadolinium contrast, before (dark grey line) and after (light grey line) IACS. The late enhancement ratio was calculated at 250 s (x axis). c): Box plot demonstrating the reduction in total synovial volume (cm3) after IACS. Osteoarthritis and Cartilage 2014 22, 1614-1618DOI: (10.1016/j.joca.2014.05.024) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 (Figures a–d) apply to the same study participant). a) Sagittal 3D, T1-weighted VIBE water excitation image pre-intravenous gadolinium contrast. b) Sagittal 3D, T1-weighted VIBE water excitation image, demonstrating synovial enhancement (arrowed) post-intravenous gadolinium contrast. c) Difference image (post-contrast minus pre-contrast) demonstrating areas of synovial enhancement after intravenous gadolinium contrast. Semi-automatic segmentation of the enhancing synovium was performed from such difference images of the entire knee joint and the 3D segmentation was overlaid on the 4D dynamic series to calculate values for mean synovial SI for each dynamic series. d) Mean synovial SI curves pre- and post-IACS. Osteoarthritis and Cartilage 2014 22, 1614-1618DOI: (10.1016/j.joca.2014.05.024) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions