Hyaluronic acid hydrogel functionalized with self-assembled micelles of amphiphilic pegylated kartogenin for the treatment of osteoarthritis M.-L. Kang,

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Hyaluronic acid hydrogel functionalized with self-assembled micelles of amphiphilic pegylated kartogenin for the treatment of osteoarthritis M.-L. Kang, J. Se-Yeong, G.-I. Im Osteoarthritis and Cartilage Volume 25, (April 2017) DOI: 10.1016/j.joca.2017.02.054 Copyright © 2017 Terms and Conditions

Fig. 1 Morphology by SEM of free PEG/KGN micelles (A), covalently integrated-PEG/KGN micelles in HA (B) and lyophilized HA/PEG/KGN hydrogel (C). Size distribution by DLS of free PEG/KGN micelles (A) and covalently integrated-PEG/KGN micelles in HA (B). Osteoarthritis and Cartilage 2017 25, DOI: (10.1016/j.joca.2017.02.054) Copyright © 2017 Terms and Conditions

Fig. 2 Histological and biochemical analysis to evaluate the chondroprotective effect of HA/PEG/KGN hydrogels after IA injection into OA rats. Representative image of knee joints: Safranin O staining and immunohistochemistry for COL2 and aggrecan at 8 weeks after the first IA injection (A). Naive rat knee joint is also shown as a normal control. The graph shows the OARSI (B) and Mankin (C) scores in the medial tibial plateau. Data are presented as mean ± SD (N = 10). [*p< 0.05, **p< 0.001]. Osteoarthritis and Cartilage 2017 25, DOI: (10.1016/j.joca.2017.02.054) Copyright © 2017 Terms and Conditions