Interleukin-1 region meta-analysis with osteoarthritis phenotypes G. Moxley, I. Meulenbelt, K. Chapman, C.M. van Diujn, P. Eline Slagboom, M.C. Neale, A.J.P. Smith, A.J. Carr, J. Loughlin  Osteoarthritis and Cartilage  Volume 18, Issue 2, Pages 200-207 (February 2010) DOI: 10.1016/j.joca.2009.08.006 Copyright © 2009 Terms and Conditions

Fig. 1 Meta-analytic overview of OA phenotypes according to data about extended haplotype formed by IL1A (rs1800587), IL1B (rs1143634–rs1143627–rs16944), and IL1RN (rs419598–intron 2 VNTR–rs315952). “Panel” indicates primary site of study panel. “Risk Eht” is the 7-marker extended haplotype 1111221 representing major alleles at all loci except rs419598 and intron 2 VNTR that has previously been reported as associated with hip OA and with hand OA. “DSL OR” is DerSimonian & Laird OR for random effects49 and “MH OR” Mantel–Haenzel OR, both as implemented in R software package meta. Numbers representing probable risk extended haplotypes and total 7-marker extended haplotypes are the summed probabilities within each OA phenotype or control group. Q represents Cochran's test for study heterogeneity between or among panels and is tested as χ2 with df, degrees of freedom. I2 is Higgins & Thompson's index reflecting variation attributable to study heterogeneity (low<25%, medium 25–75%, high>75%41,42). Each panel's OR is graphically indicated by position of square and 95% CI by line; study weighting is shown by size of square for each panel; and each summary OR and CI are indicated by the diamond's respective center and horizontal dimension. All summary ORs have CIs overlapping unity and therefore are not statistically significant. Osteoarthritis and Cartilage 2010 18, 200-207DOI: (10.1016/j.joca.2009.08.006) Copyright © 2009 Terms and Conditions