Giulia Caglio, Elena Torlai Triglia, Ana Pombo Cell Stem Cell

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Presentation transcript:

Keep Them Close: PRC2 Poises Enhancer-Promoter Interactions at Anterior Neuronal Genes Giulia Caglio, Elena Torlai Triglia, Ana Pombo Cell Stem Cell Volume 20, Issue 5, Pages 573-575 (May 2017) DOI: 10.1016/j.stem.2017.04.006 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Schematic of Regulation of Gene Activation through Poised Enhancers during Anterior Neuronal Differentiation Above: Poised enhancers in mouse ESCs are already in contact with their target genes. Upon differentiation, PRC2 is lost, enhancers acquire an active state (marked by H3K27ac), and the target genes are transcribed. Below: In the absence of PRC2 (PRC2 KO), poised enhancers lose H3K27me3 and do not contact their target genes in ESCs. Upon differentiation the enhancers fail to activate and do not acquire H3K27ac, and target genes are not transcribed. It is unclear whether RNAPII is also lost from promoters in these conditions. Cell Stem Cell 2017 20, 573-575DOI: (10.1016/j.stem.2017.04.006) Copyright © 2017 Elsevier Inc. Terms and Conditions