Combined heart-kidney transplant improves post-transplant survival compared with isolated heart transplant in recipients with reduced glomerular filtration.

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Presentation transcript:

Combined heart-kidney transplant improves post-transplant survival compared with isolated heart transplant in recipients with reduced glomerular filtration rate: Analysis of 593 combined heart-kidney transplants from the United Network Organ Sharing Database Tara Karamlou, MD, Karl F. Welke, MD, D. Michael McMullan, MD, Gordon A. Cohen, MD, Jill Gelow, MD, Frederick A. Tibayan, MD, James M. Mudd, MD, Matthew S. Slater, MD, Howard K. Song, MD The Journal of Thoracic and Cardiovascular Surgery Volume 147, Issue 1, Pages 456-461.e1 (January 2014) DOI: 10.1016/j.jtcvs.2013.09.017 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Horizontal bar graph depicting the number of isolated heart transplants performed in each year of the study period. Actual numerical value depicted on the right side, with calendar year on the left side. B, Horizontal bar graph depicting the number of combined heart-kidney transplants performed in each year of the study period. Actual numerical value depicted on the right side, with calendar year on the left side. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 456-461.e1DOI: (10.1016/j.jtcvs.2013.09.017) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Kaplan-Meier plot depicting post-transplant survival among isolated heart transplant recipients (red line) compared with post-transplant survival among combined heart-kidney transplant recipients. Note that survival is equivalent among both groups. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 456-461.e1DOI: (10.1016/j.jtcvs.2013.09.017) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Kaplan-Meier plot depicting post-transplant survival among isolated heart-transplant recipients stratified by glomerular filtration rate (GFR) quintiles. Note that recipients in the lowest GFR quintile (GFR <37 mL/minute [red line]) had significantly lower survival compared with the other 4 groups. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 456-461.e1DOI: (10.1016/j.jtcvs.2013.09.017) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Kaplan-Meier plot depicting the post-transplant survival among isolated heart transplant recipients in the lowest glomerular filtration rate (GFR) quintile (GFR <37 mL/minute [black line]) compared with post-transplant survival among combined heart-kidney transplant recipients (red line). Although overall survival was equivalent among both isolated heart transplant and combined organ transplant recipients, there is a significant survival advantage when a combined transplant strategy is used compared with isolated heart transplant in the subgroup of patients with GFR <37 mL/minute. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 456-461.e1DOI: (10.1016/j.jtcvs.2013.09.017) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions