GT repeats are unique to Cdk6 and are conserved in different mammals.

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GT repeats are unique to Cdk6 and are conserved in different mammals. GT repeats are unique to Cdk6 and are conserved in different mammals. Schematic representation of different Cdk genes, including coding exons (■) UTRs (□) and introns. (A) Human Cdk6 and the closely related Cdk4 and Cdk2 are shown. Highlighted in human Cdk6 are the GT repeat sequences. Two stretches ranging from 10 to 40 repeats are found in introns 1, 3, and 4. The repeats located at the 3′ UTR of the gene are 400 nt downstream of the stop codon and 180 nt upstream of the first polyadenylation site. In contrast to Cdk6, Cdk4, and Cdk2 have significantly shorter introns and 3′ UTR and lack GT repeat sequences. (B) TG repeats are present in primates, mouse, and rat Cdk6 genes. The length of the introns is more or less conserved, i.e., introns 1, 2, 3, and 4 are >35-Kb long, whereas introns 5 and 6 range from 1 to 5 Kb. Although chicken Cdk6 gene structure is similar to that of other vertebrates analyzed, the sequence lacks GT repeats entirely. Youhna M. Ayala et al. PNAS 2008;105:10:3785-3789 ©2008 by National Academy of Sciences