Effects of desflurane on cerebral autoregulation

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Effects of desflurane on cerebral autoregulation N.M. Bedforth, K.J. Girling, H.J. Skinner, R.P. Mahajan British Journal of Anaesthesia Volume 87, Issue 2, Pages 193-197 (August 2001) DOI: 10.1093/bja/87.2.193 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Middle cerebral artery flow velocity during a typical transient hyperaemic response test. The flow velocity decreases suddenly at the onset of compression of ipsilateral common carotid artery and, if the autoregulation is intact, shows hyperaemic response at the release of compression. The pulse wave form immediately before the onset of compression (F1), immediately after the onset of compression (F2) and that immediately after the release of compression (F3) are taken for calculating the transient hyperaemic response ratio and strength of autoregulation. British Journal of Anaesthesia 2001 87, 193-197DOI: (10.1093/bja/87.2.193) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 2 Middle cerebral artery (MCA) flow velocity (FV) for the eight patients before induction of anaesthesia and during anaesthesia maintained with desflurane at end-tidal concentrations of 7.4 and 10.8%. The thin lines show changes for each individual and the thick line shows mean changes. The changes were insignificant. British Journal of Anaesthesia 2001 87, 193-197DOI: (10.1093/bja/87.2.193) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 3 The transient hyperaemic response ratio (THRR) for the eight patients before induction of anaesthesia and during anaesthesia maintained with desflurane at end-tidal concentrations of 7.4 and 10.8%. The thin lines show changes for each individual and the thick line shows mean changes. The changes were significant (P<0.001). British Journal of Anaesthesia 2001 87, 193-197DOI: (10.1093/bja/87.2.193) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 4 The strength of autoregulation (SA) for the eight patients before induction of anaesthesia and during anaesthesia maintained with desflurane at end-tidal concentrations of 7.4 and 10.8%. The thin lines show changes for each individual and the thick line shows mean changes. The changes were significant (P<0.001). British Journal of Anaesthesia 2001 87, 193-197DOI: (10.1093/bja/87.2.193) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions