Sequential use of letrozole and gonadotrophin in women with poor ovarian reserve: a randomized controlled trial Vivian Chi Yan Lee, Carina Chi Wai Chan,

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Presentation transcript:

Sequential use of letrozole and gonadotrophin in women with poor ovarian reserve: a randomized controlled trial Vivian Chi Yan Lee, Carina Chi Wai Chan, Ernest Hung Yu Ng, William Shu Biu Yeung, Pak Chung Ho Reproductive BioMedicine Online Volume 23, Issue 3, Pages 380-388 (September 2011) DOI: 10.1016/j.rbmo.2011.05.012 Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Flow diagram of patient participation in the trial. Reproductive BioMedicine Online 2011 23, 380-388DOI: (10.1016/j.rbmo.2011.05.012) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Serum hormone concentrations on various days of ovarian stimulation. (A) Oestradiol concentrations of the letrozole group were significantly lower than the control group from day 4 to the day of HCG (all P-values<0.001). (B) FSH concentrations of the letrozole and control groups were comparable on most days, except on day 8 when FSH concentration of the letrozole group was significantly lower than that of the control group (P<0.001). (C) LH concentrations of the letrozole group were significantly higher than the control groups on days 4, 6 and 8 (P=0.018, P<0.001 and P=0.018, respectively). HCG=human chorionic gonadotrophin; ∗significantly different values. Reproductive BioMedicine Online 2011 23, 380-388DOI: (10.1016/j.rbmo.2011.05.012) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions