Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children C. Jeleazcov, H. Ihmsen,

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Presentation transcript:

Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children C. Jeleazcov, H. Ihmsen, J. Schmidt, C. Ammon, H. Schwilden, J. Schüttler, J. Fechner British Journal of Anaesthesia Volume 100, Issue 4, Pages 509-516 (April 2008) DOI: 10.1093/bja/aem408 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 BIS and the predicted plasma concentrations of propofol, remifentanil, and fentanyl obtained with the used pharmacokinetic models from the literature in each patient. British Journal of Anaesthesia 2008 100, 509-516DOI: (10.1093/bja/aem408) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Measured and fitted values of BIS together with the CHWSS scores (a) in response to the predicted plasma concentrations (b) in one 8-yr-old male patient. British Journal of Anaesthesia 2008 100, 509-516DOI: (10.1093/bja/aem408) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 Residual errors for BIS during anaesthesia. Errors are expressed as (measured–predicted value) in percentage of individual baseline effect E0. Each line shows the values of one individual patient. Predictions were made with the individual pharmacodynamic parameters. British Journal of Anaesthesia 2008 100, 509-516DOI: (10.1093/bja/aem408) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Equilibration rate constant ke0 of propofol (a) and time to peak propofol concentration Tpeak Propofol (b) as a function of age. British Journal of Anaesthesia 2008 100, 509-516DOI: (10.1093/bja/aem408) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions