A New KIT Gene Mutation in Thymic Cancer and a Promising Response to Imatinib Sung Hee Lim, MD, Ji-Yun Lee, MD, Jong-Mu Sun, MD, PhD, Kyoung-Mee Kim,

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A New KIT Gene Mutation in Thymic Cancer and a Promising Response to Imatinib Sung Hee Lim, MD, Ji-Yun Lee, MD, Jong-Mu Sun, MD, PhD, Kyoung-Mee Kim, MD, PhD, Jin Seok Ahn, MD, PhD, Myung-Ju Ahn, MD, PhD, Keunchil Park, MD, PhD Journal of Thoracic Oncology Volume 8, Issue 10, Pages e91-e92 (October 2013) DOI: 10.1097/JTO.0b013e31829d51bd Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Thymic carcinoma in a patient with an activating KIT mutation before treatment with imatinib: hematoxylin and eosin (×400) (A), immunohistochemical KIT staining (×400) (B). Journal of Thoracic Oncology 2013 8, e91-e92DOI: (10.1097/JTO.0b013e31829d51bd) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Chest CT images at baseline and after 15 months of imatinib treatment showed a decrease in size with cystic change of the anterior mediastinal mass (A); the right pleural-based mass had nearly disappeared and pleural effusion decreased (B). Positron emission tomography–CT scans at the same time points also showed decreased FDG uptake in the corresponding lesions of the anterior mediastinum (C) and pleura (D). CT, computed tomography; FDG, fluorodeoxyglucose. Journal of Thoracic Oncology 2013 8, e91-e92DOI: (10.1097/JTO.0b013e31829d51bd) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions