John L. Yovich, Kevin N. Keane, Gayatri Borude, Satvinder S

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Presentation transcript:

Finding a place for corifollitropin within the PIVET FSH dosing algorithms John L. Yovich, Kevin N. Keane, Gayatri Borude, Satvinder S. Dhaliwal, Peter M. Hinchliffe Reproductive BioMedicine Online Volume 36, Issue 1, Pages 47-58 (January 2018) DOI: 10.1016/j.rbmo.2017.09.017 Copyright © 2017 Terms and Conditions

Figure 1 PIVET rFSH dosing algorithm designed for ~8.3 IU increments up to 300 IU suited to the Puregon pen; coloured red. For dosages ≥300 IU, increments of 25 IU suit both Puregon and Gonal-f pens; coloured orange. Dosages of 200–400 IU rFSH daily can be replaced by Elonva (100 µg or 150 µg according to the woman's weight; covers for 7 days); coloured green. Reproductive BioMedicine Online 2018 36, 47-58DOI: (10.1016/j.rbmo.2017.09.017) Copyright © 2017 Terms and Conditions

Figure 2 PIVET rFSH dosing algorithm designed for 12.5 IU increments up to 300 IU suited to the Gonal-f pen; coloured red. For dosages ≥300 IU, increments of 25 IU suit both Puregon and Gonal-f pens; coloured orange. Dosages of 200–400 IU rFSH daily can be replaced by Elonva (100 µg or 150 µg according to the woman's weight; covers for 7 days); coloured green. Reproductive BioMedicine Online 2018 36, 47-58DOI: (10.1016/j.rbmo.2017.09.017) Copyright © 2017 Terms and Conditions

Figure 3 Mean (±SD) number of oocytes recovered at oocyte retrieval categorized according to AFC grouping (A) and rFSH dosage (B). Ovarian stimulation was conducted with Elonva (closed grey circles; n = 155 cycles) or with standard rFSH (open black squares; 872 (A) and 894 (B) cycles). The response of oocyte retrieval was analysed using a best fit regression line, and the slopes compared statistically. In addition, the mean oocyte yield for each AFC group was compared between treatments using ANOVA. No statistical difference was observed between treatments for regression slopes or mean comparisons. Reproductive BioMedicine Online 2018 36, 47-58DOI: (10.1016/j.rbmo.2017.09.017) Copyright © 2017 Terms and Conditions