TGF-β signaling and collagen deposition in chronic rhinosinusitis

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Staphylococcus aureus sensitization and allergic disease in early childhood: Population- based birth cohort study Aida Semic-Jusufagic, MD, Claus Bachert,

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo Eli O. Meltzer, MD, Claus Bachert,

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3 Feng Lan, MD, Nan Zhang,

Russell S. Traister, MD, PhD, Crystal E. Uvalle, BS, Gregory A

Endotype-driven care pathways in patients with chronic rhinosinusitis

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3 Feng Lan, MD, Nan Zhang,

The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic.

Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois Bruce K. Tan, MD, MS, Aiko I. Klingler, PhD,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis Hyun-Woo Shin, MD, PhD, Dong-Kyu Kim, MD, Min-Hyun Park, MD,

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.

Increased TGF-β2 in severe asthma with eosinophilia

Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation

Oral steroids and doxycycline: Two different approaches to treat nasal polyps Thibaut Van Zele, MD, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels,

Obesity impairs apoptotic cell clearance in asthma

Chronic rhinosinusitis in Asia

Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3 Se Jin Park,

Is 9 more than 2 also in allergic airway inflammation?

Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in patients with chronic rhinosinusitis and their possible contribution to local glucocorticoid.

Evidence of a role for B cell–activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps Atsushi Kato, PhD,

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis Philippe Gevaert, MD, PhD, Nicholas Van Bruaene, MD, Tom Cattaert,

T-cell regulation in chronic paranasal sinus disease

Role of TWIK-related potassium channel-1 in chronic rhinosinusitis

Staphylococcus aureus enhances the tight junction barrier integrity in healthy nasal tissue, but not in nasal polyps Can Altunbulakli, MSc, Rita Costa,

Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma Muhannad Hassan, MD, Taisuke Jo, MD, PhD, Paul-André Risse, PhD,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps Sarah Peterson, MD, Julie A. Poposki, MS, Deepti.

Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania Xiangdong Wang, MD, PhD,

Tertiary lymphoid organs in recalcitrant chronic rhinosinusitis

RAGE processing in chronic airway conditions: Involvement of Staphylococcus aureus and ECP Koen Van Crombruggen, PhD, Gabriele Holtappels, Natalie De.

Physician needs in health informatics: Just ask the docs

Cross-talk between human mast cells and epithelial cells by IgE-mediated periostin production in eosinophilic nasal polyps Dae Woo Kim, MD, PhD, Marianna.

The quest for autoreactive antibodies in nasal polyps

Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5.

David D. Tieu, MD, Anju T. Peters, MD, Roderick T

Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps Chengshuo Wang, MD, Hongfei Lou,

Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma Muhannad Hassan, MD, Taisuke Jo, MD, PhD, Paul-André Risse, PhD,

The Editors' Choice Journal of Allergy and Clinical Immunology

Src homology 2 domain–containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung Sun-Young Oh, PhD,

Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps Tetsuji Takabayashi, MD, Atsushi Kato, PhD,

IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis Hyun-Woo Shin, MD, PhD, Dong-Kyu Kim, MD, Min-Hyun Park, MD,

Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo Eli O. Meltzer, MD, Claus Bachert,

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Allergic fungal rhinosinusitis—more than a fungal disease?

Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease Nan Zhang, MD, PhD, Thibaut Van Zele, MD, PhD, Claudina.

Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis Akira Matsuda, MD, PhD, Nobuyuki Ebihara, MD, PhD, Norihiko.

The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection Saurabh Mehandru, MD, Klara Tenner-Racz, MD, Paul Racz, MD, PhD, Martin.

Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools Valérie Bougault, PhD, Lionel Loubaki, MSc,

Eosinophilic esophagitis treated with immunotherapy to dust mites

Long-term pathologic consequences of acute irritant-induced asthma

Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps Joke Patou, MD, Philippe Gevaert, MD, PhD, Thibaut.

The extra domain A of fibronectin is essential for allergen-induced airway fibrosis and hyperresponsiveness in mice Martin Kohan, MSc, Andres F. Muro,

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy.

Asthma: The past, future, environment, and costs

Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania Xiangdong Wang, MD, PhD,

Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis Jennifer K. Mulligan, PhD, Whitney Nagel,

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma Philippe Gevaert, MD, PhD, Lien Calus, MD, Thibaut Van Zele,

Immunopathology of atopic dermatitis

Natural history of cow’s milk allergy

Chitinases and chitinase-like proteins in TH2 inflammation and asthma

Presentation transcript:

TGF-β signaling and collagen deposition in chronic rhinosinusitis Nicholas Van Bruaene, MD, Lara Derycke, PhD, Claudina Angela Perez-Novo, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels, Natalie De Ruyck, Claude Cuvelier, MD, PhD, Paul Van Cauwenberge, MD, PhD, Claus Bachert, MD, PhD Journal of Allergy and Clinical Immunology Volume 124, Issue 2, Pages 253-259.e2 (August 2009) DOI: 10.1016/j.jaci.2009.04.013 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 ELISA measurements for TGF-β 1 and 2, expressed as pg/mL. Tissue homogenates were prepared from control tissue (inferior turbinate), CRSsNP, and CRSwNP. CON, Controls. Journal of Allergy and Clinical Immunology 2009 124, 253-259.e2DOI: (10.1016/j.jaci.2009.04.013) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 TGF-β RI, II, and III mRNA expression measured by means of RT-PCR in controls, CRSsNP, and CRSwNP. Data are expressed normalized relative expression units/30 ng cDNA. CON, Controls. Journal of Allergy and Clinical Immunology 2009 124, 253-259.e2DOI: (10.1016/j.jaci.2009.04.013) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Immunostaining for TGF-β 1 (A-C) and 2 (D-F) and TGF-β RI (G-I) and II (J-L) in controls, CRSsNP, and CRSwNP. Epithelium, basal membrane, and subepithelial region are shown at a final magnification of 400×. Con, Controls. Journal of Allergy and Clinical Immunology 2009 124, 253-259.e2DOI: (10.1016/j.jaci.2009.04.013) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Immunostaining for pSmad 2 in controls (A and D), CRSsNP (B and E), and CRSwNP (C and F). Positive intranuclear staining is indicated by an arrow. Picrosirius red stainings for collagen in controls, CRSsNP, and CRSwNP, first viewed in bright-field microscopy (G-I), and viewed under polarized light (J-L) to assess fiber thickness. Con, Controls. Journal of Allergy and Clinical Immunology 2009 124, 253-259.e2DOI: (10.1016/j.jaci.2009.04.013) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 A, Quantification by means of image analysis of the number of pSmad 2–positive cells in controls, CRSsNP, and CRSwNP. B, Quantification by means of image analysis of total collagen content in controls, CRSsNP, and CRSwNP. CON, Controls. Journal of Allergy and Clinical Immunology 2009 124, 253-259.e2DOI: (10.1016/j.jaci.2009.04.013) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions