Cancer Metabolism: Is Glutamine Sweeter than Glucose?

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Presentation transcript:

Cancer Metabolism: Is Glutamine Sweeter than Glucose? Weiqin Lu, Helene Pelicano, Peng Huang Cancer Cell Volume 18, Issue 3, Pages 199-200 (September 2010) DOI: 10.1016/j.ccr.2010.08.017 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Effect of Oncogenic Signals on Glutamine Metabolism through Regulation of Glutaminase The interconnection between glutamine metabolism and glucose metabolism is also shown. Inhibition of glutaminase by compound 968 suppresses oncogenic transformation induced by Rho GTPases. GLS, glutaminase; TCA cycle, tricarboxylic acid cycle; MRC, mitochondrial respiratory chain; V, mitochondrial respiratory complex V; OAA, oxaloacetate; Asp, aspartate; α-KG, α-ketoglutarate. Cancer Cell 2010 18, 199-200DOI: (10.1016/j.ccr.2010.08.017) Copyright © 2010 Elsevier Inc. Terms and Conditions