Seung-Kee Min, MD, PhD, Richard D. Kenagy, PhD, Joseph P

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Presentation transcript:

Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery Seung-Kee Min, MD, PhD, Richard D. Kenagy, PhD, Joseph P. Jeanette, DO, Alexander W. Clowes, MD Journal of Vascular Surgery Volume 47, Issue 5, Pages 1039-1047 (May 2008) DOI: 10.1016/j.jvs.2007.12.043 Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 1 Experimental model of wrapping. Polytetrafluoroethylene graft material was placed around the external iliac arteries. The tight segment was made by wrapping the collapsed artery and a 2.5-mm-diameter rod together and removing the rod after sewing the edges of the graft material together. Journal of Vascular Surgery 2008 47, 1039-1047DOI: (10.1016/j.jvs.2007.12.043) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 2 The effect of wrapping and high blood flow on (A) iliac artery medial cross-sectional area, (B) nuclear number, (C) and nuclear density. Left panel, Arteries 4 days after wrapping. Right panel, Arteries 28 days after wrapping. Loose wrap, clear bars; tight wrap, filled bars. Results are presented as the percentage of the unwrapped control. All values are the mean ± standard error of the mean (n = 5). *P ≤ .05 vs unwrapped artery; †P ≤ .06. Journal of Vascular Surgery 2008 47, 1039-1047DOI: (10.1016/j.jvs.2007.12.043) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 3 A, Quantitation of terminal deoxy nucleotidyl transferase-mediated deoxy-uridine-triphosphate nick end labeling (TUNEL) staining of unwrapped (open bars), loosely wrapped (gray bars), and tightly wrapped (solid bars) iliac arteries at 4 days (n = 5). There were no significant differences. B, Quantitation of macrophages (CD68) in unwrapped (open bars), loosely wrapped (gray bars), and tightly wrapped (solid bars) iliac arteries at 4 days (n = 5). There were no significant differences. C, Photomicrograph (original magnification ×200) of CD68 immunostaining of tightly wrapped artery at 28 days. In order from top to bottom, the arrows point to the internal elastic lamina, the external elastic lamina, and the polytetrafluoroethylene (PTFE)/adventitia border. Journal of Vascular Surgery 2008 47, 1039-1047DOI: (10.1016/j.jvs.2007.12.043) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 4 Left panels, Picrosirius red staining (original magnification ×200) for collagen under (left panels) bright field or (right panels) polarized light of (top panels) unwrapped or (bottom panels) tightly wrapped arteries at 28 days. The arrows indicate the medial-adventitial boundary. Journal of Vascular Surgery 2008 47, 1039-1047DOI: (10.1016/j.jvs.2007.12.043) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 5 A, Alcian blue staining for glycosaminoglycans including hyaluronan (low magnesium chloride) in a (left panel) 28-day normal flow unwrapped artery and a (right panel) tightly wrapped artery (*polytetrafluoroethylene wrap; original magnification ×100). B, Verhoff's stain for elastin in a (left panel) 28-day normal flow unwrapped artery and a (right panel) tightly wrapped artery (original magnification ×200). C, Immunohistochemical staining for decorin in a (left panel) 28-day normal flow unwrapped artery and a (right panel) tightly wrapped artery (*indicates medial decorin staining; arrows indicate the medial-adventitial boundary; original magnification ×200.) Journal of Vascular Surgery 2008 47, 1039-1047DOI: (10.1016/j.jvs.2007.12.043) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions