Visualizing the Immune Synapse

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Presentation transcript:

Visualizing the Immune Synapse Abraham Kupfer Biology of Blood and Marrow Transplantation Volume 13, Pages 115-119 (January 2007) DOI: 10.1016/j.bbmt.2006.11.009 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Bidirectional intercellular communication between T cells and APCs through the IS. During a productive interaction between an antigen-specific T cell and an APC, the engaged receptors at the IS segregate into spatially distinct SMACs. Intracellular signaling proteins and cytoskeletal proteins that are associated with the ligated receptors directly or indirectly segregate along with the receptors into the different SMACs. Note that SMACs are formed in T cells and APCs, but, because different receptors are present on both cells, different signals will be produced in each. Biology of Blood and Marrow Transplantation 2007 13, 115-119DOI: (10.1016/j.bbmt.2006.11.009) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions