Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact  Joshua C. Black, Capucine Van Rechem, Johnathan R. Whetstine  Molecular Cell  Volume 48, Issue 4, Pages 491-507 (November 2012) DOI: 10.1016/j.molcel.2012.11.006 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 History, Mechanism, and Specificity of KMTs and KDMs (A) Timeline chronicling important milestones in KMT and KDM research. (B) Schematic depicting generalized reaction mechanisms of KMTs and KDMs. (C) Schematic depicting substrate specificity of KMTs and KDMs. Molecular Cell 2012 48, 491-507DOI: (10.1016/j.molcel.2012.11.006) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 2 Distribution of Histone Methylation, KMTs, and KDMs from Genome-wide Profiling Studies The distribution of methyl modifications is shown relative to chromosomal location, as well as in relationship to active and inactive genes. Green represents euchromatic regions, while red coloring represents heterochromatic regions. Distributions of modifications are represented by bars, and gradients were derived from metagene analysis published as part of the genome-wide data sets from the work of numerous labs. We have included plots from metagene analyses that included both a transcription start site (TSS) and a transcription termination site (TTS). Enzymes marked with an ∗ indicate the distribution depicted from metagene analyses that did not include both a TSS and TTS or from distributions published as heatmaps centered on the TSS. In the active gene model, the green E represents expressed exons, while the red E represents a nonexpressed exon. I denotes introns. Distributions uncovered in specific species are indicated by the following: Y, Saccharomyces cerevisiae; D, Drosophila. The lack of a denotation indicates conservation across multiple species. BV denotes bivalent genes, NBV denotes nonbivalent genes, HOX denotes patterns at Hox genes, and ZNF denotes zinc finger genes. This figure is the compiled work of numerous laboratories. We apologize for being unable to reference everyone’s contributions due to space limitations. Molecular Cell 2012 48, 491-507DOI: (10.1016/j.molcel.2012.11.006) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 3 Histone Methylation as Well as KMTs and KDMs Are Dynamically Regulated during the Cell Cycle Solid shapes denote published information for the levels or functions of the indicated enzymes and modifications during that phase of cell cycle. Histone methylation positions and degree are indicated above the cell-cycle bar, and KMTs and KDMs are indicated below the cell-cycle bar. The white square denotes that the indicated enzyme is important during this time in cell cycle but that expression levels over cell cycle have not been reported. This figure is compiled from work generated by numerous groups. We apologize for being unable to reference everyone’s contributions due to space limitations. Molecular Cell 2012 48, 491-507DOI: (10.1016/j.molcel.2012.11.006) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 4 KMTs and KDMs Are Dynamically Regulated through Multiple Mechanisms KMTs and KDMs are subject to inhibition or activation through the regulatory mechanisms that are indicated. Molecular Cell 2012 48, 491-507DOI: (10.1016/j.molcel.2012.11.006) Copyright © 2012 Elsevier Inc. Terms and Conditions