Preoperative platelet function predicts perioperative bleeding complications in ticagrelor- treated cardiac surgery patients: a prospective observational.

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Presentation transcript:

Preoperative platelet function predicts perioperative bleeding complications in ticagrelor- treated cardiac surgery patients: a prospective observational study C.J. Malm, E.C. Hansson, J. Åkesson, M. Andersson, C. Hesse, C. Shams Hakimi, A. Jeppsson British Journal of Anaesthesia Volume 117, Issue 3, Pages 309-315 (September 2016) DOI: 10.1093/bja/aew189 Copyright © 2016 The Author(s) Terms and Conditions

Fig 1 Scatter plot of preoperative adenosine diphosphate (ADP)-induced aggregation and time since last dose of ticagrelor in ticagrelor-treated subjects. There was a linear correlation between the tested variables (R2=0.30, P<0.001). British Journal of Anaesthesia 2016 117, 309-315DOI: (10.1093/bja/aew189) Copyright © 2016 The Author(s) Terms and Conditions

Fig 2 Receiver operating characteristic curve for the precision of adenosine diphosphate (ADP)-induced aggregation to predict severe bleeding. The cut-off value (22 U) had a sensitivity of 76% and a specificity of 75%. British Journal of Anaesthesia 2016 117, 309-315DOI: (10.1093/bja/aew189) Copyright © 2016 The Author(s) Terms and Conditions

Fig 3 The distribution of the preoperative adenosine diphosphate (ADP)-induced aggregation values. The upper portion of the figure shows a scatter plot of the ADP-induced aggregation of the subjects with severe bleeding. The normal range of ADP-induced aggregation (43–100 U) is marked by a green background. British Journal of Anaesthesia 2016 117, 309-315DOI: (10.1093/bja/aew189) Copyright © 2016 The Author(s) Terms and Conditions

Fig 4 Probability of severe bleeding in relation to the preoperative adenosine diphosphate (ADP)-induced aggregation. The grey area represents the 95% confidence interval. British Journal of Anaesthesia 2016 117, 309-315DOI: (10.1093/bja/aew189) Copyright © 2016 The Author(s) Terms and Conditions