D. E. Karageorgopoulos, J. -M. Qu, I. P. Korbila, Y. -G. Zhu, V. A

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Accuracy of β-D-glucan for the diagnosis of Pneumocystis jirovecii pneumonia: a meta- analysis D.E. Karageorgopoulos, J.-M. Qu, I.P. Korbila, Y.-G. Zhu, V.A. Vasileiou, M.E. Falagas Clinical Microbiology and Infection Volume 19, Issue 1, Pages 39-49 (January 2013) DOI: 10.1111/j.1469-0691.2011.03760.x Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Flow diagram for the process of selection of articles for inclusion in the meta-analysis from PubMed search results. Clinical Microbiology and Infection 2013 19, 39-49DOI: (10.1111/j.1469-0691.2011.03760.x) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Forest plot of the bivariate meta-analysis of the sensitivity and specificity of (1 → 3)-β-D-glucan for the diagnosis of Pneumocystis jirovecii pneumonia. The circles in squares and horizontal lines represent the point estimate and 95% confidence interval, respectively, for each included study; the dotted line represents the average point estimate; the diamond shape represents the 95% confidence interval of the average estimate. Clinical Microbiology and Infection 2013 19, 39-49DOI: (10.1111/j.1469-0691.2011.03760.x) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Summary hierarchical receiver operating characteristics (HSROC) curve of the sensitivity vs. specificity of (1 → 3)-β-D-glucan for the diagnosis of Pneumocystis jirovecii pneumonia. The straight line represents the HSROC curve; the shaded diamond shape represents the point of the curve that corresponds to the average point estimates of sensitivity and specificity; the dashed line represents the 95% confidence area for this point; the numbered circles represent the data from each of the included studies; and the dotted line (the 95% prediction contour) represents the 95% confidence area in which a new relevant study will be located. Clinical Microbiology and Infection 2013 19, 39-49DOI: (10.1111/j.1469-0691.2011.03760.x) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions