Michael S. Dodd et al. BTS 2018;3:

Slides:

Advertisements

Similar presentations

Von Hippel-Lindau Syndrome

Advertisements

Volume 84, Issue 3, Pages (September 2013)

Targeting HIF2α in Clear-Cell Renal Cell Carcinoma

HIF1a Pathway ProteinLounge.com Glucose Glucose Glucose Transporter

The effect of suppressing HIF1A on the expression of HIF2A

Locatelli et al. Am J Nephrol 2017;45: (DOI: / )

Nat. Rev. Nephrol. doi: /nrneph

HIFs: a-cute answer to inflammation?

Prolyl‐hydroxylase‐domain proteins regulate hypoxia inducible factor‐α in response to O2 availability. Prolyl‐hydroxylase‐domain proteins regulate hypoxia.

E2F7/8 and HIF1 are required for hypoxic VEGFA expression.

Chung S. Lim, MRCS, PhD, Serafim Kiriakidis, PhD, Ewa M

by Javier Navarro-Antolín, Konstantin L

The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent

Chung S. Lim, MRCS, PhD, Serafim Kiriakidis, PhD, Ewa M

von Hippel-Lindau Disease

HIF1 binds and stimulates the VEGFA promoter in normoxia.

Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2α activity Takuya Hashimoto,

Sirtuins and the Metabolic Hurdles in Cancer

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease

Management of advanced renal cancer

Figure 5 Regulation of inflammation by metabolites

PK-M2 Makes Cells Sweeter on HIF1

Volume 78, Issue 9, Pages (November 2010)

Basic Research in Kidney Cancer

INT-767 treatment prevents the increase in renal HIF and Glut1 expression and ER stress in diabetic DBA/2J mice. INT-767 treatment prevents the increase.

Volume 141, Issue 2, Pages e5 (August 2011)

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Hamid R. Rezvani, Nsrein Ali, Lars J

Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions Garrick K. Wilson, Daniel A. Tennant,

Volume 15, Issue 3, Pages (April 2016)

Fig. 5. Stimulation of EPO expression and secretion under hypoxic culture conditions. Stimulation of EPO expression and secretion under hypoxic culture.

Figure 1 Involvement of pVHL in cellular physiology and RCC

William G. Kaelin, Peter J. Ratcliffe Molecular Cell

Heloise Mongue-Din et al. BTS 2017;2:

Targeting HIF2α in Clear-Cell Renal Cell Carcinoma

Volume 84, Issue 3, Pages (September 2013)

Hypoxia-inducible factor pathway and diseases of the vascular wall

The Hypoxic Response: Huffing and HIFing

LIMD1 expression is regulated by hypoxia

Y. Henrotin, Ph.D., B. Kurz, Ph.D., T. Aigner, M.D.DSc.

Michael S. Dodd et al. BTS 2018;3:

Volume 107, Issue 1, Pages 1-3 (October 2001)

The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent

Into Thin Air: How We Sense and Respond to Hypoxia

N H N H Figure S1 parp-1 +/+ parp-1 -/- HIF-2 DAPI

Insight from the Air–Skin Interface

Low oxygen stimulates the immune system

Mutations of von Hippel-Lindau Tumor-Suppressor Gene and Congenital Polycythemia Yves Pastore, Katerina Jedlickova, Yongli Guan, Enli Liu, James Fahner,

Endothelial Cells Form a Phalanx to Block Tumor Metastasis

EMT and proteinuria as progression factors

Volume 78, Issue 1, Pages (July 2010)

Angiotensin II: breathtaking in the renal medulla

Inflammation and hypoxia in the kidney: friends or foes?

LIMD1 hypoxic induction occurs via HIF‐1 and facilitates formation of a hypoxic HIF‐1 degradation complex LIMD1 hypoxic induction occurs via HIF‐1 and.

Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes

Volume 76, Issue 5, Pages (September 2009)

Regulation of Intestinal Iron Absorption: The Mucosa Takes Control?

PK-M2 Makes Cells Sweeter on HIF1

Adipose tissue dysfunction induces increased liver HIF-1α expression

Schematic diagram of the HIF-signalling system and zebrafish homologues. Schematic diagram of the HIF-signalling system and zebrafish homologues. (A) Proteins.

Fig. 4 Deletion of hepatocyte HIF-2α does not affect obesity-induced glucose, glucagon, and insulin intolerance. Deletion of hepatocyte HIF-2α does not.

Hypoxia decreases lipogenesis via mTORC1 signalling in lymphocytes

Fig. 3. Inhibition of HIF1α with chrysin induced cell death and suppressed the expressions of glycolysis-regulating genes in GBMs. (A~D) Cell viability.

VHL-, oxygen-, and proteasome-dependent regulation of AUF1 expression in RCC and 293T cells. VHL-, oxygen-, and proteasome-dependent regulation of AUF1.

PX-478 inhibits hypoxic HIF-1 protein expression and signaling activity in a dose-dependent manner. PX-478 inhibits hypoxic HIF-1 protein expression and.

Gramicidin A (GA) decreases HIF protein expression in RCC cells.

Vandetanib decreases tumor incidence and accumulation of HIF-2α, expression of c-Myc and growth factor receptors in the lung of hypoxic mice. Vandetanib.

Expression of HIF-1α and β-catenin in hypoxic HCC cell lines and HAL-treated xenografts. Expression of HIF-1α and β-catenin in hypoxic HCC cell lines and.

Connections between insulin/insulin-like growth factor 1 signaling and metabolic pathways in tumor cells. Connections between insulin/insulin-like growth.

Presentation transcript:

Michael S. Dodd et al. BTS 2018;3:485-498 IR Impairs HIF-1α Protein Accumulation and Downstream Signaling (A to C) HIF-1α protein accumulation and downstream targets GLUT1 and cyclophilin B protein levels following normoxia and hypoxia, in control and insulin resistant cardiomyocytes. (D) Hypoxia-sensitive phospho-activating transcription factor (pATF) 1 protein levels following normoxia and hypoxia, in control and insulin-resistant (IR) cardiomyocytes. (E and F) mRNA expression of Hif1A, Hif1B, prolyl hydroxylase domain enzymes (Phd) 2 and 3, factor inhibiting HIF (Fih), and von-Hippel Lindau (vhl), in normoxic control and insulin resistant cardiomyocytes. *p < 0.05 versus normoxic control, #p < 0.05 versus normoxic insulin resistant, $p < 0.05 versus hypoxic control, Ψp < 0.05 versus effect of oxygen at 2-way analysis of variance. A.U. = arbitrary units. Michael S. Dodd et al. BTS 2018;3:485-498 2018 The Authors