House Dust Mite Respiratory Allergy: An Overview of Current Therapeutic Strategies Moisés A. Calderón, MD, PhD, Jörg Kleine-Tebbe, MD, Allan Linneberg,

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House Dust Mite Respiratory Allergy: An Overview of Current Therapeutic Strategies Moisés A. Calderón, MD, PhD, Jörg Kleine-Tebbe, MD, Allan Linneberg, MD, PhD, Frédéric De Blay, MD, PhD, Dolores Hernandez Fernandez de Rojas, MD, PhD, Johann Christian Virchow, MD, FRCP, FCCP, Pascal Demoly, MD, PhD The Journal of Allergy and Clinical Immunology: In Practice Volume 3, Issue 6, Pages 843-855 (November 2015) DOI: 10.1016/j.jaip.2015.06.019 Copyright © 2015 The Authors Terms and Conditions

Figure 1 Search methodology. Methodology of individual and composite literature searches to identify literature relevant to AR and/or AA related to HDMs, and their treatment. Additional specific searches were conducted using asthma, allergic rhinitis, and dust mite, with interventions as associated keywords, and filters applied for publication type (meta-analysis, clinical trial) and age of publication up to 2013. Categories of evidence are based on Shekelle et al,43 adapted by Cox et al.44 The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 843-855DOI: (10.1016/j.jaip.2015.06.019) Copyright © 2015 The Authors Terms and Conditions

Figure 2 The risk of development of new asthma symptoms is high in AR. The highest risk of novel asthma symptoms in a general population of Danish adults was found for those with HDM-related AR.52 The y-axis refers to the percentage of patients with AR related to sensitization to pollens, animals, or HDMs who developed asthma symptoms, grouped by the presence or absence of AR at the start of the study. 95% CIs are indicated. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 843-855DOI: (10.1016/j.jaip.2015.06.019) Copyright © 2015 The Authors Terms and Conditions

Figure 3 A, A summary of efficacy data for AIT in AR.135,136 Forest plot to indicate the reported efficacy for SCIT and SLIT in AR related to HDM and to all reported allergens. The pooled estimates are mean difference between active and placebo in total symptom scores. B, A summary of efficacy data for AIT in AA.137,138 Forest plot to indicate the reported efficacy for SCIT and SLIT in AA related to HDM and to all reported allergens. The pooled estimates are mean difference between active and placebo in total symptom scores. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 843-855DOI: (10.1016/j.jaip.2015.06.019) Copyright © 2015 The Authors Terms and Conditions