Fig. 2. Pathways differentially regulated in patients with early Lyme disease and STARI. Pathways differentially regulated in patients with early Lyme.

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Fig. 2. Pathways differentially regulated in patients with early Lyme disease and STARI. Pathways differentially regulated in patients with early Lyme disease and STARI. The 122 presumptively identified MFs were analyzed using MetaboAnalyst to identify perturbed pathways between early Lyme disease and STARI. The color and size of each circle are based on P values and pathway impact values. Pathways with a >0.1 impact were considered to be perturbed and differentially regulated between patients with early Lyme disease and STARI. A total of four pathways were affected: (i) glycerophospholipid metabolism; (ii) sphingolipid metabolism; (iii) valine, leucine, and isoleucine biosynthesis; and (iv) phenylalanine metabolism. Claudia R. Molins et al., Sci Transl Med 2017;9:eaal2717 Published by AAAS