Observations of subchondral plate advancement during osteochondral repair: a histomorphometric and mechanical study in the rabbit femoral condyle Y.-S.

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Observations of subchondral plate advancement during osteochondral repair: a histomorphometric and mechanical study in the rabbit femoral condyle Y.-S Qiu, Ph.D., B.F Shahgaldi, Ph.D., W.J Revell, Ph.D., F.W Heatley, F.R.C.S. Osteoarthritis and Cartilage Volume 11, Issue 11, Pages 810-820 (November 2003) DOI: 10.1016/S1063-4584(03)00164-X

Fig. 1 Showing the screen display of a reconstructed tidemark, and measuring sites in the repair region on a histological section. Osteoarthritis and Cartilage 2003 11, 810-820DOI: (10.1016/S1063-4584(03)00164-X)

Fig. 2 Illustrating the three measuring sites (S1–S3) across each repairing defect and the two measuring sites at the adjacent cartilage (A1, A2). The arrows indicate the boundary between the repair surface and the adjacent cartilage; (a.b.): the advanced subchondral bone; (C): articular cartilage; (T): the drawn ‘normal’ tidemark. Osteoarthritis and Cartilage 2003 11, 810-820DOI: (10.1016/S1063-4584(03)00164-X)

Fig. 3 A microfocal radiograph showing advanced subchondral bone plate at 32 weeks (indicated by arrows). Osteoarthritis and Cartilage 2003 11, 810-820DOI: (10.1016/S1063-4584(03)00164-X)

Fig. 4 Histology of repaired specimens at 8, 16 and 32 weeks. (A) There is no reconstitution of an osteochondral junction at 8 weeks. (B) The subchondral plate is irregular at 16 weeks (arrow) and (C) by 32 weeks it has advanced with consequent thinning and disintegration of repaired surface layers (arrow). Safranin-O staining is positive at 8 weeks but negative at 16 and 32 weeks (safranin-O and fast green staining, ×25). Osteoarthritis and Cartilage 2003 11, 810-820DOI: (10.1016/S1063-4584(03)00164-X)

Fig. 5 (A) Advancement of subchondral bone in comparison to native level of subchondral plate during 32-week natural healing and (B) thickness of repair surface layer in comparison to the adjacent articular cartilage at the same period (means, unpaired Student's t-test). Osteoarthritis and Cartilage 2003 11, 810-820DOI: (10.1016/S1063-4584(03)00164-X)

Fig. 6 (A) Contact pressures of normal and repaired articular surfaces (mean±SD). (B) Indentations of normal and repaired articular surfaces (mean±SD). Osteoarthritis and Cartilage 2003 11, 810-820DOI: (10.1016/S1063-4584(03)00164-X)