The prognostic significance of tumor cell detection in intraoperative pleural lavage and lung tissue cultures for patients with lung cancer J. Buhr,

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Presentation transcript:

The prognostic significance of tumor cell detection in intraoperative pleural lavage and lung tissue cultures for patients with lung cancer J. Buhr, MDa, K.H. Berghäuser, MDb, S. Gonner, MDb, C. Kelm, MDa, E.A. Burkhardt, PhDc, W.M. Padberg, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 113, Issue 4, Pages 683-690 (April 1997) DOI: 10.1016/S0022-5223(97)70225-3 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 A malignant cell in intraoperative pleural lavage fluid (lavage I) of a squamous cell carcinoma (pT2 N0, stage I, G2; Papanicolaou staining; original magnification ×500). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 683-690DOI: (10.1016/S0022-5223(97)70225-3) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Malignant cells in the sediment of intraoperative pleural lavage (lavage I, arrows) (adenocarcinoma, pT2 N0, stage I, G2-3; hematoxylin and eosin staining, original magnification ×500). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 683-690DOI: (10.1016/S0022-5223(97)70225-3) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Cytologic results in intraoperative pleural lavage (n = 342 patients). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 683-690DOI: (10.1016/S0022-5223(97)70225-3) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Four-year survival of all patients undergoing intraoperative pleural lavage, subdivided into “positive lavage” (n = 132) and “negative lavage” (n = 201) groups (p = 0.007). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 683-690DOI: (10.1016/S0022-5223(97)70225-3) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Four-year survival of patients undergoing curative resection for stage I lung cancer, divided into “positive lavage” (n = 47) and “negative lavage” (n = 114) groups, if lavage I (before resection) was positive (p = 0.037). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 683-690DOI: (10.1016/S0022-5223(97)70225-3) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 Tumor cells (small arrows) in lung tissue culture in a lymphatic vessel near a small pulmonary artery and vein (big arrows) 9 days after incubation of tumor-free lung parenchyma of an adenocarcinoma of the lung (pT2 N0; hematoxylin and eosin staining, original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 683-690DOI: (10.1016/S0022-5223(97)70225-3) Copyright © 1997 Mosby, Inc. Terms and Conditions