Serum hepatitis B core-related antigen is more accurate than hepatitis B surface antigen to identify inactive carriers, regardless of hepatitis B virus.

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Presentation transcript:

Serum hepatitis B core-related antigen is more accurate than hepatitis B surface antigen to identify inactive carriers, regardless of hepatitis B virus genotype M. Riveiro-Barciela, M. Bes, F. Rodríguez-Frías, D. Tabernero, A. Ruiz, R. Casillas, J. Vidal-González, M. Homs, L. Nieto, S. Sauleda, R. Esteban, M. Buti Clinical Microbiology and Infection Volume 23, Issue 11, Pages 860-867 (November 2017) DOI: 10.1016/j.cmi.2017.03.003 Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Comparison of mean hepatitis B surface antigen (HBsAg) and hepatitis B core-related antigen (HBcrAg) levels between inactive carriers and patients with hepatitis B virus (HBV) activity showed statistical differences in patients infected by genotype A (HBsAg and HBcrAg) and D (HBsAg), but not in those with genotypes E, F or H infection. Clinical Microbiology and Infection 2017 23, 860-867DOI: (10.1016/j.cmi.2017.03.003) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Correlations between hepatitis B virus (HBV) DNA and both hepatitis B surface antigen (HBsAg) (a) and hepatitis B core-related antigen (HBcrAg) (b) reached statistical significance. Independent analysis by each genotype showed that correlations were only present in patients infected by genotype A (HBsAg and HBcrAg) and D (only HBsAg). Moderate correlations between HBsAg and HBcrAg levels (c) were found in genotype A and D patients. Clinical Microbiology and Infection 2017 23, 860-867DOI: (10.1016/j.cmi.2017.03.003) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Correlations between hepatitis B virus (HBV) DNA and both hepatitis B surface antigen (HBsAg) (a) and hepatitis B core-related antigen (HBcrAg) (b) reached statistical significance. Independent analysis by each genotype showed that correlations were only present in patients infected by genotype A (HBsAg and HBcrAg) and D (only HBsAg). Moderate correlations between HBsAg and HBcrAg levels (c) were found in genotype A and D patients. Clinical Microbiology and Infection 2017 23, 860-867DOI: (10.1016/j.cmi.2017.03.003) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions