Frank Siebenhaar, MD, Markus Magerl, MD, Eva M. J

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Presentation transcript:

Mast cell–driven skin inflammation is impaired in the absence of sensory nerves Frank Siebenhaar, MD, Markus Magerl, MD, Eva M.J. Peters, MD, Sven Hendrix, MD, Martin Metz, MD, Marcus Maurer, MD Journal of Allergy and Clinical Immunology Volume 121, Issue 4, Pages 955-961 (April 2008) DOI: 10.1016/j.jaci.2007.11.013 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Unilateral surgical skin denervation results in loss of functional skin nerves. SN markers (A and B, PGP 9.5; C and D, SP; E and F, CGRP) are virtually undetectable 10 days after denervation (B, D, F) compared with sham-denervation (arrows in A, C, E). G, Denervated ears fail to develop inflammatory reaction in response to capsaicin. d, Dermis; dp, dermal papilla; e, epidermis; sg, sebaceous gland. ∗P < .05; ∗∗∗P < .005. Journal of Allergy and Clinical Immunology 2008 121, 955-961DOI: (10.1016/j.jaci.2007.11.013) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Passive cutaneous anaphylaxis is impaired in the absence of sensory nerves. A, Evans blue extravasation is reduced in denervated skin. B, Numbers of cutaneous and subcutaneous MCs per MF in denervated, sham-denervated, and untreated skin. C, MC degranulation in denervated skin after PCA. +P < .05, ++P < .01 comparing denervated and sham-denervated areas; ∗∗∗P < .005 comparing PCA and control areas. DNP, Dinitrophenol. Journal of Allergy and Clinical Immunology 2008 121, 955-961DOI: (10.1016/j.jaci.2007.11.013) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Sensory nerves promote MC-driven skin inflammation by the release of neuropeptides. A, Inflammatory responses to topical capsaicin in MC-deficient KitW/KitW-v and normal Kit+/+ mice. B, MC degranulation after topical capsaicin treatment. C, Inhibition of PCA-induced skin inflammation by a SP or CRGP antagonist. D, Passive systemic anaphylaxis is not impaired by antagonists of SP and CGRP. ∗∗∗P < .005, ∗P < .05 comparing PCA versus control sites; +P < .05 compared with vehicle treatment. Ant., Antagonist; DNP, dinitrophenol. Journal of Allergy and Clinical Immunology 2008 121, 955-961DOI: (10.1016/j.jaci.2007.11.013) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions