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Volume 15, Issue 3, Pages 173-179 (October 2008) Treadmill exercise training fails to reverse defects in glucose, insulin and muscle GLUT4 content in the db/db mouse model of diabetes Jacqueline Sennott, Joseph Morrissey, Paul R. Standley, Tom L. Broderick Pathophysiology Volume 15, Issue 3, Pages 173-179 (October 2008) DOI: 10.1016/j.pathophys.2008.06.001 Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Changes in body weight in control (CN, n=18), diabetic sedentary (DS, n=18), diabetic voluntary running (DV, n=12), and diabetic treadmill running mice (DT, n=12) over the 12-week period of intervention. Values are reported as mean±S.E.M. *p<0.05 compared to CN mice. †p<0.05 compared to DS mice. ‡p<0.05 compared to DV mice. Pathophysiology 2008 15, 173-179DOI: (10.1016/j.pathophys.2008.06.001) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Changes in blood glucose in control (CN, n=18), diabetic sedentary (DS, n=18), diabetic voluntary running (DV, n=12), and diabetic treadmill running mice (DT, n=12) over the 12-week period of intervention. Values are reported as mean±S.E.M. *p<0.05 compared to CN mice. †p<0.05 compared to DS mice. ‡p<0.05 compared to DV mice. Pathophysiology 2008 15, 173-179DOI: (10.1016/j.pathophys.2008.06.001) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Effect of diabetes and 12 weeks of exercise training on plasma insulin levels in control (CN, n=16), diabetic sedentary (DS, n=14), diabetic voluntary running (DV, n=12), and diabetic treadmill running (DT, n=8). Values are reported as mean±S.E.M. *p<0.05 compared to CN mice. **p<0.01 compared to CN mice. ***p<0.001 compared to CN mice. †p<0.05 compared to DS mice. Pathophysiology 2008 15, 173-179DOI: (10.1016/j.pathophys.2008.06.001) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Effect of diabetes and 12 weeks of exercise training on skeletal muscle GLUT4 levels in control (CN, n=16), diabetic sedentary (DS, n=15), diabetic voluntary running (DV, n=14), and diabetic treadmill running (DT, n=14). Values are reported as mean±S.E.M. *p<0.05 compared to CN mice. Pathophysiology 2008 15, 173-179DOI: (10.1016/j.pathophys.2008.06.001) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions