David A. Zvara, MD, David M. Colonna, MD, Dwight D. Deal, BS, Jason C

Slides:

Advertisements

Similar presentations

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease C Bjartmar, J.R Wujek, B.D Trapp Journal of.

Advertisements

Exploring Spinal Cord Protection by Remote Ischemic Preconditioning: An Experimental Study Johanna Herajärvi, MD, Tuomas Anttila, MB, Henna Sarja, MB,

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Interruption of spinal cord microglial signaling by alpha-2 agonist dexmedetomidine in a murine model of delayed paraplegia Marshall T. Bell, MD, Viktor.

Robert S Poston, Margaret E Billingham, Jeffrey Pollard, E

Jeanwan Kang, MD, Hassan Albadawi, MD, Patrick J. Casey, MD, Thomas A

Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia Fang He, MD, Enyi Shi, MD, PhD, Lihui Yan, MD, Juchen.

Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury Ren-Ke Li, MD, PhD, Donald A.G. Mickle,

Preoperative stress conditioning prevents paralysis after experimental aortic surgery: Increased heat shock protein content is associated with ischemic.

Early ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusion Ioannis K. Toumpoulis,

Superiority of early relative to late ischemic preconditioning in spinal cord protection after descending thoracic aortic occlusion Ioannis K. Toumpoulis,

Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia Enyi Shi, MD, PhD, Xiaojing.

Ischemic postconditioning protects the spinal cord from ischemia–reperfusion injury via modulation of redox signaling Wenying Song, MD, Jing Sun, MD,

Preconditioning protects the severely atherosclerotic mouse heart

Intrathecal transplantation of bone marrow stromal cells attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia-reperfusion injury.

Robert S Poston, Margaret E Billingham, Jeffrey Pollard, E

Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice Bao-Ngoc Nguyen, MD, Hassan Albadawi, MD, Rahmi Oklu,

Reduction of ischemic spinal cord injury by dextrorphan: Comparison of several methods of administration Hitoshi Terada, MD, Teruhisa Kazui, MD, Makoto.

Protective use of N-methyl-d-aspartate receptor antagonists as a spinoplegia against excitatory amino acid neurotoxicity Yasunori Cho, MD, Toshihiko.

Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn.

Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits Hironori Baba, MD, Yoshihisa Tanoue, MD, PhD, Taketoshi.

Loic Lang-Lazdunski, MDa,b. , Catherine Heurteaux, PhDb

Protection of rat spinal cord from ischemia with dextrorphan and cycloheximide: Effects on necrosis and apoptosis Hiroyuki Kato, MD, PhDa c, Georgios.

Regeneration of Dorsal Column Fibers into and beyond the Lesion Site following Adult Spinal Cord Injury Simona Neumann, Clifford J Woolf Neuron Volume.

The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model Yujiro Kawanishi, MD, Kenji Okada, MD, Hiroshi.

Prevention of ischemic spinal cord injury: Comparative effects of magnesium sulfate and riluzole Loïc Lang-Lazdunski, MD, Catherine Heurteaux, PhD, Hervé.

Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion Patrick.

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats Loïc Lang-Lazdunski, MD, PhD, Nicolas Blondeau,

Combination of preconditioning and delayed flap elevation: evidence for improved perfusion and oxygenation of the latissimus dorsi muscle for cardiomyoplasty

Sevoflurane Attenuates Ischemia-Reperfusion Injury in a Rat Lung Transplantation Model Akihiro Ohsumi, MD, Katherine Marseu, MD, Peter Slinger, MD, Karen.

The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation T.

Experimental study on the protective effects of edaravone against ischemic spinal cord injury Kazuchika Suzuki, MD, Teruhisa Kazui, MD, PhD, Hitoshi.

Prevention of paraplegia in pigs by selective segmental artery perfusion during aortic cross-clamping Sven A. Meylaerts, MDa, Peter de Haan, MD, PhDb,

Cold spinoplegia and transvertebral cooling pad reduce spinal cord injury during thoracoabdominal aortic surgery Mitsuhiro Isaka, MD, Hajime Kumagai,

The neuroprotective effects of intrathecal administration of the selective N-type calcium channel blocker ziconotide in a rat model of spinal ischemia

Neuroprotection following mild hypothermia after spinal cord ischemia in rats Takeshi Saito, PhD, Shino Saito, MD, Hiroshi Yamamoto, MD, PhD, Masanori.

Brian T Feeley, BS, Aric K Park, BS, Sophoclis Alexopoulos, BS, E

Comparison of Systemic and Retrograde Delivery of Adenosine A2A Agonist for Attenuation of Spinal Cord Injury After Thoracic Aortic Cross-Clamping T.

Exogenous aspartate neurotoxicity in the spinal cord under metabolic stress in vivo Yasunori Cho, MD, Toshihiko Ueda, MD, Atsuo Mori, MD, Tsukasa Nakamichi,

Neuronal Cell Death in the Ischemic Spinal Cord: The Effect of Methylprednisolone Georgios K. Kanellopoulos, MD, Hiroyuki Kato, MD, PhD, Yingji Wu, MSc,

Interleukin-1 receptor antagonist attenuates the severity of spinal cord ischemic injury in rabbits Satoshi Akuzawa, MD, Teruhisa Kazui, MD, PhD, Enyi.

Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction Shigetoshi.

Prolonged 24-hour subzero preservation of heterotopically transplanted rat hearts using antifreeze proteins derived from arctic fish Gabriel Amir, MD,

Inhibition of MicroRNA-204 Conducts Neuroprotection Against Spinal Cord Ischemia Lihui Yan, MD, Enyi Shi, MD, PhD, Xiaojing Jiang, MD, PhD, Jiang Shi,

Protection by 20-5,14-HEDGE Against Surgically Induced Ischemia Reperfusion Lung Injury in Rats Irshad Ali, PhD, Stephanie Gruenloh, BS, Ying Gao, MS,

Immunoglobulin G4-Related Disease Presenting as an Obstructing Tracheal Mass: Consideration of Surgical Indications Edward M. Kobraei, MD, Tae H. Song,

Effects of thoracic aortic occlusion and cerebrospinal fluid drainage on regional spinal cord blood flow in dogs: Correlation with neurologic outcome

Dose-dependent neuroprotection of delta-opioid peptide [D-Ala2, D-Leu5] enkephalin on spinal cord ischemia-reperfusion injury by regional perfusion into.

Spinal cord injury in experimental thoracic aortic occlusion: investigation of combined methods of protection James R. Elmore, MD, Peter Gloviczki, MD,

Remote ischemic preconditioning protects the spinal cord against ischemic insult: An experimental study in a porcine model Henri Haapanen, MD, Johanna.

Volume 25, Issue 2, Pages (February 2000)

Ugursay Kiziltepe, MD, N. Nilufer D Turan, PhD, Unsal Han, MD, A

New method for absolute spinal cord ischemia protection in rabbits

Ischemic preconditioning ameliorates spinal cord ischemia-reperfusion injury by triggering autoregulation Cheng-Loong Liang, MD, Kang Lu, MD, PhD, Po-Chou.

Overexpression of microRNA-21 protects spinal cords against transient ischemia Fang He, MD, PhD, Yixing Ren, MD, Enyi Shi, MD, PhD, Kun Liu, MD, Lihui.

Shankha S Biswas, Edward P Chen, Hartmuth B Bittner, R

Myogenic transcranial motor evoked potentials monitoring cannot always predict neurologic outcome after spinal cord ischemia in rats Manabu Kakinohana,

The adenosine triphosphate–sensitive potassium channel opener nicorandil protects the ischemic rabbit spinal cord Yutaka Wakamatsu, MDa, Norihiko Shiiya,

Reactive hyperemia during early reperfusion as a determinant of improved functional recovery in ischemic preconditioned rat hearts Annie Rochetaing,

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Lazaroid reduces production of IL-8 and IL-1 receptor antagonist in ischemic spinal cord injury Takashi Kunihara, MD, Shigeyuki Sasaki, MD, Norihiko.

Heat shock improves recovery and provides protection against global ischemia after hypothermic storage Ashok Gowda, MS, Chunjie Yang, MD, Gregory K Asimakis,

Ischemia-reperfusion injury of the spinal cord: Protective effect of the hydroxyl radical scavenger dimethylthiourea Willem Wisselink, MD, Samuel R.

Effects of an Angiotensin II Antagonist on Ischemic and Nonischemic Isolated Rat Hearts Yosef Paz, Jacob Gurevitch, Inna Frolkis, Menachem Matsa, Amir.

Monitoring of intrathecal oxygen tension during experimental aortic occlusion predicts ultrastructural changes in the spinal cord Anders Hellberg, MDa,

Left heart bypass during descending thoracic aortic aneurysm repair does not reduce the incidence of paraplegia Joseph S Coselli, MD, Scott A LeMaire,

Failure of motor evoked potentials to predict neurologic outcome in experimental thoracic aortic occlusion James R. Elmore, MD, Peter Gloviczki, MD,

Cannabinoid 1 receptor mediation of spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats Binxiao Su, MD, Hailong Dong,

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

Presentation transcript:

Ischemic preconditioning reduces neurologic injury in a rat model of spinal cord ischemia David A. Zvara, MD, David M. Colonna, MD, Dwight D. Deal, BS, Jason C. Vernon, BS, Mamatha Gowda, BS, John C. Lundell, MD The Annals of Thoracic Surgery Volume 68, Issue 3, Pages 874-880 (September 1999) DOI: 10.1016/S0003-4975(99)00559-7

Fig 1 Heart rate, mean proximal aortic pressure, and mean distal aortic pressure during experimental protocol for control group (CTRL) and ischemic preconditioning group (IPC). (BL = baseline; IPC = 3-minute period of aortic occlusion, or ischemic preconditioning; ISC = 12-minute prolonged ischemic insult; REP-1 = 30-minute reperfusion interval; REP-2 = period of reperfusion after ISC [closure of surgical wounds and recovery of animal]; — = interval of significant difference between groups.) The Annals of Thoracic Surgery 1999 68, 874-880DOI: (10.1016/S0003-4975(99)00559-7)

Fig 2 Data from the four motor neurologic tests (Tarlov scale, righting, placing, and inclined plane) were combined for a composite neurologic score and are presented as a box plot. The scores are shown in Table 1 and are summated for each animal. A score of 10 indicates complete motor neurologic deficit, whereas a 0 indicates a normal animal. Mann-Whitney rank sum test demonstrated significant difference between groups at both time points. (CTRL = control group; IPC = ischemic preconditioning group; boxed area = 25th to 75th percentile; — = 10th and 90th percentiles; ○ = individual animals above or below 10th and 90th percentiles; broken line = median value for group.). The Annals of Thoracic Surgery 1999 68, 874-880DOI: (10.1016/S0003-4975(99)00559-7)

Fig 3 Photomicrograph of ventral horn of lumbar spinal cord (L5) from rat in ischemic preconditioning group with motor deficit score of 0 48 hours after injury. The gray matter architecture is clearly conserved and shows healthy surviving motor neurons (hatched arrowheads) and relatively low numbers of infiltrates (black arrowheads) in response to the limited damage. The few atrophied and darkly stained neurons (white arrowheads) are an artifact of formalin fixation. Laminae 6 through 10 are numbered and outlined according to Rexed’s criteria [21]. (Hematoxylin and eosin; ×10 before % reduction.) The Annals of Thoracic Surgery 1999 68, 874-880DOI: (10.1016/S0003-4975(99)00559-7)

Fig 4 Photomicrograph of ventral horn of lumbar spinal cord (L5) from control rat with motor deficit score of 10 48 hours after aortic occlusion. The process of necrosis is evidenced by the shrunken, anuclear, darkly stained acidophilic motor neurons (hatched arrowheads) and the neuronal phagia (lesions characterized by a remnant empty space left by phagocytized neurons) (black arrowhead). Also typical of necrosis is the marked increase in basophilic infiltrates, which densely surround the microvasculature and diffusely occur around necrotic tissue (white arrowheads). Laminae 6 through 10 are numbered and outlined according to Rexed’s criteria [21]. (Hematoxylin and eosin; ×10 before % reduction.) The Annals of Thoracic Surgery 1999 68, 874-880DOI: (10.1016/S0003-4975(99)00559-7)