Volume 142, Issue 4, Pages 726-729.e3 (April 2012) Enteropathy-Associated T-Cell Lymphoma Complicating an Autoimmune Enteropathy  Georgia Malamut, Virginie Verkarre, Céline Callens, Orianne Colussi, Gabriel Rahmi, Elizabeth Macintyre, Corinne Haïoun, Bertrand Meresse, Nicole Brousse, Serge Romana, Olivier Hermine, Nadine Cerf–Bensussan, Christophe Cellier  Gastroenterology  Volume 142, Issue 4, Pages 726-729.e3 (April 2012) DOI: 10.1053/j.gastro.2011.12.040 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Histologic characteristics. (A–C) AIE (×100): duodenal biopsy performed 6 years before lymphoma showing (A) subtotal VA, and increased numbers of (B) CD8+ IEL and (C) LP lymphocytes. (D–F) EATL (×200): dense infiltrate of (D) medium to large cells expressing (E) CD8 and (F) granzyme B. Gastroenterology 2012 142, 726-729.e3DOI: (10.1053/j.gastro.2011.12.040) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 (A) Amplification of TCRγ VγfI-Jγ1/2 (JP1.1/1.2) rearrangements showed minor clonal peaks in the duodenum in 2001, one of which corresponded in size (255 bp) to the rearrangement identified in the lymphoma in 2008. (B) Amplification of TCRβ Vβ-Jβ2 rearrangements showed minor clonal peaks in the duodenum in 2001, one of which corresponded in size (252 bp) to the rearrangement identified in the lymphoma in 2008. (C) Molecular characteristics. Chromosomal imbalances detected by array CGH in EATL (International System for Human Cytogenetic Nomenclature 2009 nomenclature). Gastroenterology 2012 142, 726-729.e3DOI: (10.1053/j.gastro.2011.12.040) Copyright © 2012 AGA Institute Terms and Conditions

Supplementary Figure 1 Endoscopic features of EATL relapse. EATL was shown in the irregular and ulcerative stricture observed in the proximal small bowel by double-balloon enteroscopy. Gastroenterology 2012 142, 726-729.e3DOI: (10.1053/j.gastro.2011.12.040) Copyright © 2012 AGA Institute Terms and Conditions

Supplementary Figure 2 Analysis of TCRγ rearrangement in 3 control AIE patients. Analysis of TCRγ rearrangement identified by amplifying TCRγ V-J junctional regions in polymerase chain reaction (PCRs) using 2 distinct mixes (B' and C') performed in duodenal specimens of 3 AIE patients (patients 2, 3, and 4): a minor clonal rearrangement (V11-Jg1/2) was observed in patient 2 (arrow). Gastroenterology 2012 142, 726-729.e3DOI: (10.1053/j.gastro.2011.12.040) Copyright © 2012 AGA Institute Terms and Conditions